据报道，垂体神经内分泌肿瘤（PitNET）接受常规蝶鞍照射后，继发性脑肿瘤、颈动脉狭窄和中风的风险更高。立体定向放射外科 (SRS) 是一种更有针对性的方法，现在越来越多地使用。目的是评估 SRS 后继发性脑肿瘤、颈动脉狭窄/闭塞和中风的风险。在这项多中心回顾性研究中，研究了 2,254 名 PitNET 患者，其中暴露组 1,377 名，对照组 877 名。共有 9,840.1 名患者- SRS 组的风险年数和对照组的风险年数为 5,266.5 年。 SRS 组继发性颅内肿瘤的 15 年累积概率为 2.3% (95%CI:0.5%, 4.1%)，对照组为 3.7% (95%CI:0%, 8.7%) (p=0.6)，发病率分别为每千人 1.32 例和每千人 0.95 例。按年龄分层时，SRS 与肿瘤发生风险增加无关（HR：1.59 [95％CI：0.57，4.47]，p = 0.38）。 SRS 组中新发颈动脉狭窄/闭塞的 15 年概率为 0.9% (95%CI: 0.2, 1.6)，对照组为 2% (95%CI: 0, 4.4) (p=0.8)。 SRS 组的 15 年卒中概率为 2.6%（95%CI：0.6%、4.6%），对照组为 11.1%（95%CI：6%、15.9%）（p<0.001）。在按年龄分层的 cox 多变量分析中，SRS（HR 1.85[95%CI:0.64, 5.35]，p=0.26）与新发中风风险无关。长期继发性脑肿瘤、新发狭窄或闭塞的风险没有增加在本研究中，通过影像学监测，与对照组相比，SRS 组出现了中风。© 作者 2024。由牛津大学出版社代表神经肿瘤学会出版。版权所有。如需商业重复使用，请联系 reprints@oup.com 获取转载和转载的翻译权。所有其他权限都可以通过我们网站文章页面上的权限链接通过我们的 RightsLink 服务获得 - 如需了解更多信息，请联系journals.permissions@oup.com。

Higher risk of secondary brain tumor, carotid stenosis and stroke has been reported after conventional sella irradiation for pituitary neuroendocrine tumors (PitNET). Stereotactic radiosurgery (SRS), which is a more focused approach, is now increasingly used instead. The aim was to assess the risk of secondary brain tumor, carotid stenosis/occlusion and stroke after SRS.In this multicentric retrospective study, 2,254 patients with PitNET were studied, 1,377 in the exposed group and 877 in the control group.There were 9,840.1 patient-years at risk for the SRS and 5,266.5 for the control group. The 15-year cumulative probability of secondary intracranial tumor was 2.3% (95%CI:0.5%, 4.1%) for SRS and 3.7% (95%CI:0%, 8.7%) for the control group (p=0.6), with an incidence rate of 1.32 per 1,000 and 0.95 per 1,000, respectively. SRS was not associated with increased risk of tumorigenesis when stratified by age (HR: 1.59 [95%CI: 0.57, 4.47], p=0.38). The 15-year probability of new carotid stenosis/occlusion was 0.9% (95%CI: 0.2, 1.6) in the SRS and 2% (95%CI: 0, 4.4) in the control group (p=0.8). The 15-year probability of stroke was 2.6% (95%CI: 0.6%, 4.6%) in the SRS and 11.1% (95%CI: 6%, 15.9%) in the control group (p<0.001). In cox multivariate analysis stratified by age, SRS (HR 1.85[95%CI:0.64, 5.35], p=0.26) was not associated with risk of new stroke.No increased risk of long-term secondary brain tumor, new stenosis or occlusion and stroke was demonstrated in SRS group compared to control in this study with imaging surveillance.© The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.