肿瘤微环境中的异常 Siglec 表达与肿瘤恶性肿瘤有关，并可能影响肿瘤行为和患者生存。除此之外，与唾液酸聚糖的结合会诱导掩蔽抗原识别并促进免疫逃避，从而突出免疫功能失调。这就需要阐明它们在肿瘤进展中的表达谱。 MicroRNA (miRNA) 介导的靶向代表了一种进一步阐明 Siglec 潜力和临床相关性的新方法。尽管 Siglec 表达中的 miRNA 活性仍然有限，但我们重点介绍当前详细介绍 miRNA:Siglec 在肿瘤领域内相互作用的文献，并为针对 Siglec/唾液酸轴的可能诊断和治疗策略提供见解。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

Aberrant Siglec expression in the tumour microenvironment has been implicated in tumour malignancies and can impact tumour behaviour and patient survival. Further to this, engagement with sialoglycans induces masked antigen recognition and promotes immune evasion, highlighting deregulated immune function. This necessitates the elucidation of their expression profiles in tumour progression. MicroRNAs (miRNAs) mediated targeting represents a novel approach to further elucidate Siglec potential and clinical relevance. Although miRNA activity in Siglec expression remains limited, we highlight current literature detailing miRNA:Siglec interactions within the tumour landscape and provide insights for possible diagnostic and therapeutic strategies in targeting the Siglec/sialic acid axis.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.