阻断平滑胆固醇化：克服癌症耐药性的策略。
Blocking smoothened cholesterylation: A strategy for overcoming drug resistance in cancer.
发表日期：2024 Jul 18
作者：
Steven Y Cheng, Ying E Zhang
来源：
Cell Chemical Biology
摘要：
在本期《细胞化学生物学》中，Liu 等人1 报告了 Q29 的鉴定，这是一种合成二萜类化合物，可阻断平滑胆固醇共价修饰 (SMO) 并抑制刺猬信号传导。 Q29 能够在体外和体内抑制肿瘤细胞生长，并克服对 SMO 抑制剂的耐药性。版权所有 © 2024 Elsevier Ltd。保留所有权利。
In this issue of Cell Chemical Biology, Liu et al.1 report the identification of Q29, a synthetic diterpenoid that blocks covalent cholesterol modification of smoothened (SMO) and inhibits hedgehog signaling. Q29 is capable of suppressing tumor cell growth, both in vitro and in vivo, and overcoming resistance to SMO inhibitors.Copyright © 2024 Elsevier Ltd. All rights reserved.