转录因子依赖性可识别 BAF 依赖性癌症。
Transcription factor dependencies identify BAF-dependent cancers.
发表日期:2024 Aug 12
作者:
Helen M McRae, Diana C Hargreaves
来源:
CANCER CELL
摘要:
在《癌细胞》中,Bolomsky 等人、Duplaquet 等人和 He 等人。鉴定依赖于 BAF 染色质重塑复合物的癌症,特别是 IRF4 驱动的多发性骨髓瘤和 POU2F3 亚型小细胞肺癌,突出了 BAF 复合物抑制剂/降解剂的潜在治疗应用。版权所有 © 2024 Elsevier Inc. 保留所有权利。
In Cancer Cell, Bolomsky et al., Duplaquet et al., and He et al. identify cancers that are dependent on the BAF chromatin remodeling complex, specifically IRF4-driven multiple myeloma and POU2F3-subtype small cell lung cancer, highlighting potential therapeutic applications for BAF complex inhibitors/degraders.Copyright © 2024 Elsevier Inc. All rights reserved.