外淋巴调节性 T 细胞-树突状细胞相互作用代表了癌症免疫抑制的新轴。
Perilymphatic regulatory T cell-dendritic cell interactions represent a novel axis of immunosuppression in cancer.
发表日期：2024 Aug 12
作者：
Carolina Mangana, Barbara B Maier
来源：
CANCER CELL
摘要：
树突状细胞是适应性抗肿瘤免疫的关键诱导剂。然而，它们的成熟、激活和迁移通常在肿瘤微环境中受到损害。在本期中，您等人。展示了通过与外淋巴龛中的调节性 T 细胞相互作用介导的树突状细胞功能抑制的新轴。版权所有 © 2024 Elsevier Inc. 保留所有权利。
Dendritic cells are critical inducers of adaptive anti-tumor immunity. However, their maturation, activation, and migration are often compromised in the tumor microenvironment. In this issue, You et al. demonstrate a novel axis of suppression of dendritic cell function mediated by interaction with regulatory T cells in perilymphatic niches.Copyright © 2024 Elsevier Inc. All rights reserved.