尽管内镜下粘膜切除术 (EMR) 对炎症性肠病 (IBD) 中横向扩散病变 (LSL) 的作用仍存在争议，但其在普通人群中的有效性仍存在争议。我们的目的是与无 IBD 的对照组相比，描述 IBD 相关 LSL 的 EMR 结果。我们对接受 EMR 和内镜下 LSL 随访的 IBD 患者与无 IBD 的对照组进行比较，进行回顾性观察队列研究。主要结局是组织学复发；次要结局包括整块切除和不良事件。使用多变量混合效应逻辑回归确定与复发相关的因素。共纳入 155 名患者的 210 个癌前病变。从组织学来看，91% 为腺瘤/低度不典型增生或无蒂锯齿状病变。 IBD 组的平均病灶大小为 22.9 毫米（SD 11.3 毫米），对照组为 21.5 毫米（SD 12.4 毫米）。 IBD 相关病变的复发率为 30.4% (7/23)，而对照组的复发率为 20.9% (39/187；OR=2.51，CI 0.59-10.71)。与对照组 (106/187, 57.9%, 95% CI 50.4-65.2) 相比，整块切除在 IBD 组中较少见 (2/23, 8.7%, 95% CI 1.1-28.0)。调整病灶大小和组织学后，与对照组相比，IBD 患者的复发更为常见（OR=3.08，95% CI 1.04-9.13）。EMR 后 IBD 患者的 LSL 复发更为常见。鉴于复杂性增加，IBD 患者的 EMR 应在具有密切内窥镜监测的专家中心进行。Thieme。版权所有。

The role of endoscopic mucosal resection (EMR) for laterally spreading lesions (LSLs) in inflammatory bowel disease (IBD) remains controversial despite its effectiveness in the general population. We aim to characterize outcomes of EMR for IBD-associated LSLs compared to controls without IBD.We performed a retrospective observational cohort study of patients with IBD who underwent EMR and endoscopic follow-up for LSLs, compared to a control group without IBD. The primary outcome was histologic recurrence; secondary outcomes included en bloc resection and adverse events. Factors associated with recurrence were identified using multivariate mixed effects logistic regression.A total of 210 pre-malignant lesions in 155 patients were included. By histology, 91% were adenoma/low-grade dysplasia or sessile serrated lesions. Average lesion size was 22.9 mm (SD 11.3 mm) in the IBD group, and 21.5 mm (SD 12.4 mm) in the control group. Recurrence occurred in 30.4% of IBD-associated lesions (7/23) compared to 20.9% of controls (39/187; OR=2.51, CI .59-10.71). En bloc resection was less common in the IBD group (2/23, 8.7%, 95% CI 1.1-28.0) versus controls (106/187, 57.9%, 95% CI 50.4-65.2). After adjusting for lesion size and histology, recurrence appeared more common in patients with IBD compared to controls (OR=3.08, 95% CI 1.04-9.13).Recurrence of LSLs after EMR appears more frequent in patients with IBD. Given the added complexity, EMR in patients with IBD should be performed in expert centers with close endoscopic surveillance.Thieme. All rights reserved.