我们调查了南方社区队列研究中罹患结直肠癌 (CRC) 的参与者中糖尿病与死亡率之间的关联。参与者（73% 非西班牙裔黑人；60% 收入<15,000 美元）是在 2002 年至 2009 年间招募的。大约每隔 5 年在入组和随访调查中自我报告糖尿病情况。 CRC 事件和死亡率是通过州登记处和国家死亡指数确定的。比例风险模型计算了 1059 名 CRC 参与者中糖尿病与总体 CRC 特异性死亡率之间的关联。诊断前的糖尿病与总体死亡率升高相关（风险比 [95% 置信区间]：(1.46[1.22-1.75])，并且调整肿瘤分期后，CRC 特异性死亡率 (1.36[1.06-1.74]))。对于非西班牙裔黑人和非西班牙裔白人参与者，观察到总体死亡率（分别为 1.35[1.10-1.66] 与 1.89[1.31-2.72]，p 交互 = 0.11）和 CRC 特异性死亡率（1.30[分别为 0.99-1.71] 与 1.77[1.06-2.95]，p-相互作用 = 0.28）。对于收入低于 15,000 美元/年的个人，总体死亡率 (1.44[1.15-1.79]) 和 CRC 特异性死亡率 (1.28[0.94-1.73]) 的关联与完整样本相似。诊断时≥10年的糖尿病患者与总死亡率 (1.71[1.37-2.13]) 和 CRC 特异性死亡率 (1.65[1.22-2.22]) 的相关性最高。诊断前糖尿病与 CRC 参与者较高的死亡率相关主要是社会经济地位较低的非西班牙裔黑人群体。该人群中糖尿病患病率较高，可能会导致结直肠癌死亡率的种族差异。© 2024。作者，获得 Springer Nature Limited 的独家许可。

We investigated associations between diabetes and mortality among participants with incident colorectal cancer (CRC) from the Southern Community Cohort Study.Participants (73% non-Hispanic Black; 60% income < $15,000) were recruited between 2002-2009. Diabetes was self-reported at enrollment and follow-up surveys at approximately 5-year intervals. Incident CRC and mortality were identified via state registries and the National Death Index. Proportional hazards models calculated associations between diabetes with overall, CRC-specific mortality among 1059 participants with incident CRC.Diabetes prior to diagnosis is associated with elevated overall (hazard ratio [95% confidence interval]: (1.46[1.22-1.75]), and CRC-specific mortality (1.36[1.06-1.74])) after adjustment for tumor stage. For non-Hispanic Black and non-Hispanic White participants, consistent associations were observed for overall (1.35[1.10-1.66] vs. 1.89[1.31-2.72], respectively, p-interaction = 0.11) and CRC-specific mortality (1.30[0.99-1.71] vs. 1.77[1.06-2.95], respectively, p-interaction = 0.28). For individuals with incomes <$15,000/year, associations with overall (1.44[1.15-1.79]) and CRC-specific mortality (1.28[0.94-1.73]) were similar to the full sample. Associations with overall (1.71[1.37-2.13]) and CRC-specific mortality (1.65[1.22-2.22]) were highest for diabetes ≥ 10 years at diagnosis.Pre-diagnosis diabetes is associated with higher mortality among participants with incident CRC from a predominantly non-Hispanic Black cohort with lower socioeconomic status. The higher prevalence of diabetes in this population may contribute to racial disparities in CRC mortality.© 2024. The Author(s), under exclusive licence to Springer Nature Limited.