NF-κB 在肿瘤增殖、迁移、侵袭和免疫逃逸中的作用。
NF-κB role on tumor proliferation, migration, invasion and immune escape.
发表日期：2024 Jul 20
作者：
Afrasyab Khan, Yao Zhang, Ningna Ma, Juanjuan Shi, Yongzhong Hou
来源：
CANCER GENE THERAPY
摘要：
核因子 kappa-B (NF-κB) 是一种核转录因子，在促进炎症中发挥关键作用，在长期炎症环境中可能导致癌症的发展。 NF-κB 的激活在肿瘤发生和进展的初始阶段至关重要，发生在癌前细胞和微环境中的细胞（如吞噬细胞、T 细胞和 B 细胞）中。 NF-κB的激活除了刺激血管生成、抑制细胞凋亡、促进肿瘤细胞生长外，还引起上皮间质转化和肿瘤免疫逃避。专注于免疫检查点分子的治疗策略通过使免疫系统激活针对肿瘤细胞的免疫反应，彻底改变了癌症治疗。本综述的重点是了解癌症背景下的 NF-κB 信号通路。© 2024。作者获得 Springer Nature America, Inc. 的独家许可。
Nuclear factor kappa-B (NF-κB) is a nuclear transcription factor that plays a key factor in promoting inflammation, which can lead to the development of cancer in a long-lasting inflammatory environment. The activation of NF-κB is essential in the initial phases of tumor development and progression, occurring in both pre-malignant cells and cells in the microenvironment such as phagocytes, T cells, and B cells. In addition to stimulating angiogenesis, inhibiting apoptosis, and promoting the growth of tumor cells, NF-κB activation also causes the epithelial-mesenchymal transition, and tumor immune evasion. Therapeutic strategies that focus on immune checkpoint molecules have revolutionized cancer treatment by enabling the immune system to activate immunological responses against tumor cells. This review focused on understanding the NF-κB signaling pathway in the context of cancer.© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.