高级别浆液性癌 (HGSC) 是上皮性卵巢癌最常见和最致命的组织学亚型。 HGSC 是一种治疗挑战，因为 80% 的诊断患者会复发，通常表现为耐药性疾病。这种化学耐药性的机制尚未完全阐明，但部分归因于 HGSC 维持干细胞表型的能力，从而能够对当前疗法产生耐药性。 Polycomb 阻遏物复合物 1 和 2 (PRC1/2) 通过沉默肿瘤抑制基因和调节干细胞参与干细胞区室的维护。这些复合物由多种多梳族 (PcG) 蛋白组成，这些蛋白在正常发育中发挥作用，当解除管制时，会导致癌症的发展 [2]。 PRC1 中包含的蛋白质包括 B 淋巴瘤小鼠莫洛尼白血病病毒插入区 (BMI1)、RING1 和 chromobox (CBX) 蛋白质。我们的目的是回顾 PRC1 的每种蛋白质成分及其促进卵巢癌化疗耐药复发和传播的机制关系。在可能的情况下，我们回顾了这些蛋白质的治疗研究。我们通过 Covidence 进行了范围界定文献综述，确定了 42 篇符合纳入标准的文章。作者确定了四篇相关文章，并使用耶鲁 MeSH 分析网格生成器来建立其他关键字和标题术语。一位医学图书馆员使用这些术语和文章在以下每个数据库中起草了初步检索策略：MEDLINE、Embase、Cochrane 图书馆和 Web of Science 核心合集，根据标题和摘要生成了 439 篇文章。摘要由作者独立审阅，确定了 77 篇文章进行全文审阅，其中 35 篇最终被排除，剩下 42 篇文章进行全面审阅。我们的综述确定了目前已知的 PRC1 亚基促进 HGSC 发展、复发和化疗耐药的机制。通过对现有科学知识进行全面审查，我们支持并指导对 PRC1 进行进一步调查，这可能会影响 HGSC 治疗方面取得有意义的进展。版权所有 © 2024 Elsevier B.V. 保留所有权利。

High grade serous carcinoma (HGSC) is the most common and the deadliest histologic subtype of epithelial ovarian cancer. HGSC is a therapeutic challenge, as it recurs in 80 % of patients diagnosed, often as chemoresistant disease. The mechanism of this chemoresistance is not fully elucidated, but it is partly attributed to the ability of HGSC to maintain a stem-like phenotype that enables development of resistance to current therapies. Polycomb Repressor Complexes 1 and 2 (PRC1/2) have been implicated in the maintenance of the stem cell compartment through silencing tumor suppressor genes and regulating stem cells. These complexes are comprised of multiple polycomb group (PcG) proteins that play a role in normal development, and when deregulated contribute to the development of cancer [2]. Proteins included in PRC1 include B lymphoma mouse Moloney leukemia virus insertion region (BMI1), RING1, and chromobox (CBX) proteins. We aimed to review each of the protein components of PRC1 and their mechanistic relationships to promoting chemoresistant recurrences and propagation of ovarian cancer. Where possible, we reviewed therapeutic investigations of these proteins. We utilized a scoping literature review through Covidence to identify 42 articles meeting criteria for inclusion. The authors identified four relevant articles and the Yale MeSH Analysis Grid Generator was used to establish additional keywords and heading terms. A medical librarian used these terms and articles to draft an initial search strategy within each of the following databases: MEDLINE, Embase, Cochrane Library, and Web of Science Core Collection, yielding 439 articles based on title and abstract. Abstracts were independently reviewed by the authors, identifying 77 articles for full text review, of which 35 were ultimately excluded, leaving 42 articles for full review. Our review identified the currently known mechanisms of the subunits of PRC1 that contribute to HGSC development, recurrence, and chemoresistance. By compiling a comprehensive review of available scientific knowledge, we support and direct further investigation into PRC1 that can affect meaningful advances in the treatment of HGSC.Copyright © 2024 Elsevier B.V. All rights reserved.