确定肥胖大鼠的心脏生物胺谱并将这些化合物与心血管疾病参数相关联。Wistar 大鼠 (n = 20) 被随机分为两组：对照组和肥胖组。肥胖是由高糖脂肪饮食引起的。评估生化参数。多普勒超声心动图和收缩压；测量心脏组织中的白细胞介素-10 (IL-10)、肿瘤坏死因子-α (TNF-α)、蛋白质羰基化、铁还原抗氧化能力 (FRAP) 和过氧化氢酶活性。 HPLC 评估了心脏生物源特征。使用Student's T 或Mann-Whitney 检验和Spearman 相关性以5% 显着性对数据进行比较。进行主成分分析 (PCA)。肥胖会导致高血压、心脏重塑和功能障碍，并使所有生化、炎症和氧化标志物失衡 (p < 0.001)。在心脏组织中发现了八种生物胺。肥胖会增加血清素，并减少胍丁胺、腐胺、尸胺和亚精胺。血清素（r = 0.534 至 0.808）与肥胖、生化参数、心脏炎症、氧化应激、高血压、心脏重塑和功能障碍呈很强的正相关（p < 0.001）。亚精胺（r = -0.560 至 -0.680）、腐胺（r = -0.532 至 -0.805）、尸胺（r ​​= -0.534 至 -0.860）和胍丁胺（r = -0.579 至 -0.884）与相同浓度呈负相关。参数（p < 0.001）。 PCA 可以区分对照组和肥胖组。心脏生物胺水平、心脏重塑和肥胖引起的功能障碍之间存在很强的相关性。心脏生物胺与肥胖中的心血管疾病之间存在关联。此外，胍丁胺、腐胺、尸胺以及主要的血清素可能是肥胖患者心血管健康的新生物标志物，有助于改善肥胖引起或非肥胖引起的CVD的诊断和治疗。然而，还需要更多的研究来支持这一结论。版权所有 © 2024 Elsevier Inc. 保留所有权利。

To identify the cardiac biogenic amine profile of obese rats and associate these compounds with parameters of cardiovascular disease.Wistar rats (n = 20) were randomly distributed into two groups: control and obese. Obesity was induced by a high-sugar fat diet. Biochemical parameters were evaluated. Doppler Echocardiography and systolic blood pressure; interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), protein carbonylation, ferric reducing antioxidant power (FRAP), and catalase activity were measured in cardiac tissue. HPLC evaluated the cardiac biogenic profile. Data were compared using the Student's T or Mann-Whitney tests and Spearman's correlation at 5% significance. The principal component analysis (PCA) was performed.Obesity generated hypertension, cardiac remodeling and dysfunction, and imbalanced all biochemical, inflammatory, and oxidative markers (p < 0.001). Eight biogenic amines were found in cardiac tissue. Obesity increased serotonin and decreased agmatine, putrescine, cadaverine, and spermidine. Serotonin (r = 0.534 to 0.808) was strong and positively correlated with obesity, biochemical parameters, cardiac inflammation, oxidative stress, hypertension, cardiac remodeling, and dysfunction (p < 0.001). Spermidine (r = -0.560 to -0.680), putrescine (r = -0.532 to -0.805), cadaverine (r = -0.534 to -0.860), and agmatine (r = -0.579 to -0.884) were inversely correlated with the same parameters (p < 0.001). PCA allowed for distinguishing the control and obese groups.There are strong correlations between cardiac biogenic amine levels, cardiac remodeling, and dysfunction resulting from obesity.There is an association between cardiac biogenic amines and cardiovascular disease in obesity. In addition, agmatine, putrescine, cadaverine, and, mainly, serotonin may be new biomarkers for cardiovascular health in obesity and help to improve the diagnosis and treatment of CVD resulting or not from obesity. However, more research is needed to support this conclusion.Copyright © 2024 Elsevier Inc. All rights reserved.