人参中的人参皂苷因其潜在的健康益处而闻名，包括抗氧化特性和潜在的抗癌作用。除了各种编码基因外，人参皂苷还通过靶向非编码 RNA 发挥功效。长链非编码RNA（lncRNA）因其参与增殖、凋亡、转移和自噬等多种癌细胞活动而受到基础和临床肿瘤学领域的广泛关注。这些事件可以通过单独的 lncRNA 或与 microRNA 或蛋白质联合来实现。本综述旨在总结人参皂苷调节的lncRNA的多种活性，重点关注其在人类疾病中通过信号通路调节靶基因的作用。我们重点介绍人参皂苷诱导的 lncRNA 表达谱的研究结果，以抑制癌细胞增殖。最后，我们讨论了利用 lncRNA 作为疾病治疗诊断标记物的潜力和挑战。© 2024 韩国人参学会。 Elsevier B.V. 的出版服务

Ginsenosides in ginseng are known for their potential health benefits, including antioxidant properties and their potential to exhibit anticancer effects. Besides a various range of coding genes, ginsenosides impose their efficacy by targeting noncoding RNAs. Long noncoding RNA ( lncRNA) has gained significant attention from both basic and clinical oncology fields due to its involvement in various cancer cell activities such as proliferation, apoptosis, metastasis, and autophagy. These events can be achieved either by lncRNA alone or in association with microRNAs or proteins. This review aims to summarize the diverse activities of lncRNAs that are regulated by ginsenosides, focusing on their role in regulating target genes through signaling pathways in human diseases. We highlight the results of studies on the expression profiles of lncRNAs induced by ginsenosides in efforts to inhibit cancer cell proliferation. Finally, we discuss the potential and challenges of utilizing lncRNAs as diagnostic markers for disease treatment.© 2024 The Korean Society of Ginseng. Publishing services by Elsevier B.V.