1976年9月，由于意大利曼弗雷多尼亚石化厂的氨洗塔爆炸，39吨砷被释放到大气中，污染了工厂及其附近的社区。本研究的目的是展示对暴露工人 45 年的跟踪结果，重点关注住宅暴露情况。我们联系了意大利总登记办公室，更新了参与灾后清理活动的人员的生命状况。感兴趣的结果是总体死亡率和特定原因死亡率。在适当的时候使用加速失效时间 (AFT) 方法来模拟死亡风险。分析中考虑了贡献 67,743 人年的 1772 名工人。对于总体死亡率，年龄调整 AFT 模型的结果显示，合同工的加速因子为 0.89 (95%CI 0.80-0.99)，这意味着与参考类别（塑料区工人）相比，生存期缩短。当考虑到潜伏期超过 20 年时，居住在曼弗雷多尼亚的工人中观察到肺癌死亡率较高。在清理活动期间接触砷较多的工人中，死亡风险增加。事实上，经计算，暴露程度较高的工人会损失 5 年的生命。此外，曼弗雷多尼亚居民的死亡率高于居住在其他地方的工人。版权所有 © 2024 作者。由 Elsevier GmbH 出版。保留所有权利。

On September 1976, due to the explosion of an ammonia-washing column at the petrochemical plant in Manfredonia (Italy), 39 tonnes of arsenic were released into the atmosphere, contaminating the plants and the neighbourhoods close to it. The aim of this study is to present the results of a 45-year follow up of exposed workers with a focus on residential exposure.We contacted Italian General Registries Offices and updated the vital status of persons involved in the clean-up activities following the disaster. The outcome of interest was the overall and cause-specific mortality. An accelerated failure time (AFT) approach was used when appropriate to model the risk of mortality.1772 workers contributing 67,743 person years were considered in the analysis. For overall mortality, results of the age-adjusted AFT model show an accelerator factor of 0.89 (95%CI 0.80-0.99) among contract workers, which means a shortening of survival in comparison to the reference category (plastic area workers). When accounting for latency greater than 20 years, higher mortality rates for lung cancer were observed among workers residing in Manfredonia.An increased risk of mortality among workers who were more exposed to arsenic during the clean-up activities has been observed. In fact, a loss of 5 years of life among more exposed workers was calculated. Furthermore, the mortality rates of residents in Manfredonia were higher than those of workers residing elsewhere.Copyright © 2024 The Authors. Published by Elsevier GmbH.. All rights reserved.