准确诊断和有效治疗需要对肿瘤的全面了解。然而，目前还没有单一的成像方式可以提供足够的信息。光声（PA）成像是一种具有高空间分辨率和检测灵敏度的混合成像技术，可与超声（US）成像相结合以提供光学和声学对比度。弹性成像可以无创地绘制生物组织的弹性分布图，反映病理状况。在这项研究中，我们将 PA 弹性成像纳入商业 US/PA 成像系统中，开发了三模态成像系统，并使用四只具有不同生理条件的小鼠对该系统进行了肿瘤检测测试。结果表明，这种三模态成像系统可以提供声学、光学和机械特性的补充信息。肿瘤的可视化和尺寸估计可以为诊断和治疗提供更全面的组织特征。© 2024 作者。由爱思唯尔有限公司出版。

A comprehensive understanding of a tumor is required for accurate diagnosis and effective treatment. However, currently, there is no single imaging modality that can provide sufficient information. Photoacoustic (PA) imaging is a hybrid imaging technique with high spatial resolution and detection sensitivity, which can be combined with ultrasound (US) imaging to provide both optical and acoustic contrast. Elastography can noninvasively map the elasticity distribution of biological tissue, which reflects pathological conditions. In this study, we incorporated PA elastography into a commercial US/PA imaging system to develop a tri-modality imaging system, which has been tested for tumor detection using four mice with different physiological conditions. The results show that this tri-modality imaging system can provide complementary information on acoustic, optical, and mechanical properties. The enabled visualization and dimension estimation of tumors can lead to a more comprehensive tissue characterization for diagnosis and treatment.© 2024 The Authors. Published by Elsevier GmbH.