生长分化因子 15 (GDF15) 是一种来自转化生长因子超家族的应激反应性细胞因子，在病理条件下在哺乳动物组织中高度表达，包括胰腺、胃和肠。特别是，GDF15 水平升高可能在各种胃肠道癌症 (GC) 的发生和进展中发挥重要作用，表明其有可能成为疾病预测和治疗的有希望的靶标。在本综述中，系统综述探讨了 GDF15 在更新了GC，以及关注GDF15相关消化系统恶性肿瘤的最新临床试验。首先总结了GDF15参与生理和病理条件调节的多种细胞途径。随后，GDF15 也被确立为一个有价值的临床指标，作为多种 GC 的预测标记。值得注意的是，还强调了针对 GDF15 的最新临床治疗方法，展示了其在减轻和治愈消化系统恶性肿瘤方面的巨大潜力。这篇综述揭示了 GDF15 的关键作用及其作为 GC 发病机制中有希望的靶点的潜力，这可能为未来提供富有洞察力的方向调查。© 2024 作者。约翰·威利 (John Wiley) 出版的《欧洲临床研究杂志》

Growth differentiation factor 15 (GDF15), a stress-responsive cytokine from transforming growth factor superfamily, is highly expressed in mammalian tissues, including pancreas, stomach and intestine under pathological conditions. In particular, elevated levels of GDF15 might play an important role in the development and progression of various gastrointestinal cancers (GCs), suggesting its potential as a promising target for disease prediction and treatment.In this review, systematic reviews addressing the role of GDF15 in GCs were updated, along with the latest clinical trials focussing on the GDF15-associated digestive malignancies.The multiple cellular pathways through which GDF15 is involved in the regulation of physiological and pathological conditions were first summarized. Then, GDF15 was also established as a valuable clinical index, functioning as a predictive marker in diverse GCs. Notably, latest clinical treatments targeting GDF15 were also highlighted, demonstrating its promising potential in mitigating and curing digestive malignancies.This review unveils the pivotal roles of GDF15 and its potential as a promising target in the pathogenesis of GCs, which may provide insightful directions for future investigations.© 2024 The Author(s). European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.