目前的指南推荐根治性肾输尿管切除术联合膀胱套切除术作为高危上尿路尿路上皮癌（UTUC）的标准手术治疗方法。虽然关于开放式和腹腔镜肾输尿管切除术有大量证据，但 UTUC 中机器人肾输尿管切除术 (RNU) 的数据大多有限，结果好坏参半，特别是在局部晚期疾病中。鉴于最近推出了新的机器人平台，进一步研究与 RNU 相关的肿瘤学结果至关重要。此外，迫切需要更强有力的数据来探索新机器人系统的不同操作设置（即机械臂和套管针放置）。为了回答此类开放性临床问题，初级 ERUS/青年学术泌尿科医生机器人辅助手术工作组设计了一个涉及世界各地不同大容量中心的多中心项目。该研究的目的将是探索 RNU 的手术和肿瘤学结果，特别关注一些未满足的临床需求，例如新机器人平台的最佳手术设置、淋巴结清扫 (LDN) 模板和机器人膀胱袖带管理。

Current guidelines recommend radical nephroureterectomy with bladder cuff excision as the standard surgical treatment for high-risk upper tract urothelial carcinoma (UTUC). While large evidence is available regarding open and laparoscopic nephroureterectomy, data focusing on robotic nephroureterectomy (RNU) in UTUC are mostly limited with mixed results, especially in locally advanced disease. In light of the recent introduction of new robotic platforms, it is of utmost importance to further investigate oncologic outcomes associated with RNU. Moreover, stronger data exploring different operative settings (i.e. robotic arms and trocars placement) for the new robotic systems are eagerly warranted. To give an answer to such open clinical questions, the Junior ERUS/Young Academic Urologist Working Group on Robot-assisted Surgery designed a multicentric project involving different high-volume centers across the world. The aim of the study will be exploring surgical and oncologic outcomes of RNU, specifically focusing on several clinical unmet needs, such as best operative setting for new robotic platforms, lymph node dissection (LDN) template and robotic bladder cuff management.