离子通道和转运蛋白在肝细胞癌中的病理生理作用。
Pathophysiological role of ion channels and transporters in hepatocellular carcinoma.
发表日期：2024 Jul 24
作者：
Li Zhang, Hong Gu, Xin Li, Yongfeng Wang, Shun Yao, Xingyue Chen, Liming Zheng, Xingyue Yang, Qian Du, Jiaxing An, Guorong Wen, Jiaxing Zhu, Hai Jin, Biguang Tuo
来源：
CANCER GENE THERAPY
摘要：
肝细胞癌（HCC）的发病率在全球范围内逐年持续增加，HCC已成为癌症相关死亡的常见原因。尽管在了解 HCC 发展的分子机制方面取得了很大进展，但 HCC 的治疗仍然是一个巨大的挑战。因此，HCC患者的生存和预后仍然极差。近年来，离子通道在疾病发病机制中的作用已成为研究热点。在正常肝组织中，离子通道和转运蛋白维持水和电解质平衡以及酸碱稳态。然而，这些离子通道和转运蛋白的功能障碍可导致HCC的发生和进展，因此这些离子通道和转运蛋白有望成为新的治疗靶点。在这篇综述中，综述了与 HCC 相关的离子通道和转运蛋白，并提出了新的有效疗法的潜在靶标。© 2024。作者。
The incidence of hepatocellular carcinoma (HCC) has continued to increase annually worldwide, and HCC has become a common cause of cancer-related death. Despite great progress in understanding the molecular mechanisms underlying HCC development, the treatment of HCC remains a considerable challenge. Thus, the survival and prognosis of HCC patients remain extremely poor. In recent years, the role of ion channels in the pathogenesis of diseases has become a hot topic. In normal liver tissue, ion channels and transporters maintain water and electrolyte balance and acid‒base homeostasis. However, dysfunction of these ion channels and transporters can lead to the development and progression of HCC, and thus these ion channels and transporters are expected to become new therapeutic targets. In this review, ion channels and transporters associated with HCC are reviewed, and potential targets for new and effective therapies are proposed.© 2024. The Author(s).