现在已知具有挑战性的机械化学环境（即具有不同的机械和粘合特性）会在运动细胞中诱发广泛的适应性现象。例如，限制和低粘附力可能会引发向快速变形虫（基于前导泡）迁移的表型转变。人们开始了解这些现象背后的分子机制。由于其尺寸，细胞核的机械特性已被证明可以限制和促进细胞迁移。此外，现在已知各种瞬时受体电位（TRP）通道的活性对于响应多种生物物理刺激的细胞迁移是不可或缺的。然而，细胞如何整合来自细胞核和质膜的信号尚不清楚。开发抑制癌症或增强免疫肿瘤学应用等免疫细胞迁移的疗法将需要额外的工作来完全理解使细胞能够在机械化学挑战性环境中导航的分子机制。版权所有 © 2024 Elsevier Ltd. 保留所有权利。

Challenging mechanochemical environments (i.e., with varied mechanical and adhesive properties) are now known to induce a wide range of adaptive phenomena in motile cells. For instance, confinement and low adhesion may trigger a phenotypic transition to fast amoeboid (leader bleb-based) migration. The molecular mechanisms that underly these phenomena are beginning to be understood. Due to its size, the mechanical properties of the nucleus have been shown to limit and facilitate cell migration. Additionally, the activity of various transient receptor potential (TRP) channels is now known to be integral to cell migration in response to a multitude of biophysical stimuli. How cells integrate signals from the nucleus and plasma membrane, however, is unclear. The development of therapeutics that suppress cancer or enhance immune cell migration for immuno-oncology applications, etc., will require additional work to completely understand the molecular mechanisms that enable cells to navigate mechanochemically challenging environments.Copyright © 2024 Elsevier Ltd. All rights reserved.