导管相关血栓（CRT）是中心静脉导管（CVC）的主要并发症。然而，重症外科患者中 CRT 的发生率、起始时间以及对 CVC 材料和/或类型的依赖性尚不清楚。因此，我们在这里调查了危重外科患者中 CRT 的发生率、发作以及对各种危险因素的依赖性，包括 CVC 材料和类型。前瞻性、研究者发起的观察性研究。一所大学的外科重症监护室六个月期间在我们的外科重症监护病房接受治疗的所有患有 CVC 的危重患者（手术：79.8%/医疗：20.2%）。无。所有 CVC 每隔一天使用超声波进行 CRT 检查，开始放置后 24 小时内。主要结果是 CRT 的开始时间，具体取决于 CVC 的类型（三到五流明，三个不同的制造商）。使用多个 Cox 比例风险回归模型分析 CRT 风险因素。我们纳入了 94 例首次颈内静脉 CVC。对于不同类型的 CVC，CRT 的中位时间从 1 到 5 天不等。一天之内，37% 至 64% 的 CVC 出现了 CRT，一周内，64% 至 100% 的 CVC 出现了 CRT。除一名 CRT 观察者外，所有其他人都没有症状，也没有引起并发症。 CRT危险因素的多元回归分析显示，除了癌症和省略预防性抗凝之外，某些类型的CVC也与CRT的较高风险相关。几乎所有危重手术患者的颈内静脉CVC在第一时间都出现无症状CRT导管插入后天数。版权所有 © 2024。由 Elsevier Inc. 出版。

Catheter-related thrombosis (CRT) is a major complication of central venous catheters (CVCs). However, the incidence, onset, and dependence of CRT on CVC material and/or type in critically ill surgical patients is unknown. Therefore, we here investigated the incidence, onset, and dependence of CRT on a variety of risk factors, including CVC material and type, in critically ill surgical patients.Prospective, investigator-initiated, observational study.A surgical intensive care unit at a university hospital.All critically ill patients with CVCs (surgical: 79.8%/medical: 20.2%) who were treated in our surgical intensive care unit during a six-month period.None.All CVCs were examined for CRT every other day using ultrasound, starting within 24 h of placement. The primary outcome was the time of onset of CRT, depending on the type of CVC (three to five lumens, three different manufacturers). The CRT risk factors were analyzed using multiple Cox proportional hazards regression models.We included 94 first-time CVCs in the internal jugular vein. The median time to CRT varied from one to five days for different types of CVCs. Within one day, 37 to 64% of CVCs and within one week, 64 to 100% of CVCs developed a CRT. All but one of the CRT observed were asymptomatic and caused no complications. Multiple regression analyses of CRT risk factors showed that beside cancer and omitting prophylactic anticoagulation, some types of CVC were also associated with a higher risk of CRT.Almost all CVCs in the internal jugular vein in critically ill surgical patients developed an asymptomatic CRT in the first days after catheterization.Copyright © 2024. Published by Elsevier Inc.