谷胱甘肽 (GSH) 是一种关键的三肽抗氧化剂，对于维持细胞氧化还原稳态和调节多种细胞过程至关重要。 GSH 的亚细胞区室化强调了它在各种细胞器中的多方面作用，包括细胞质、线粒体、内质网和细胞核，每个细胞器都表现出不同的调节机制。 GSH 动态的扰动会导致病理生理状况，强调了解其复杂调节的临床意义。这篇综述巩固了目前关于亚细胞 GSH 动力学的知识，强调了其对药物开发的影响，特别是在共价药物设计和针对细胞内 GSH 水平的抗肿瘤策略中。讨论了破译亚细胞 GSH 动力学的挑战和未来方向，倡导创新方法来提高我们的理解并促进基于 GSH 调节的精确治疗干预措施的开发。版权所有 © 2024 Elsevier Ltd. 保留所有权利。

Glutathione (GSH) is a pivotal tripeptide antioxidant essential for maintaining cellular redox homeostasis and regulating diverse cellular processes. Subcellular compartmentalization of GSH underscores its multifaceted roles across various organelles including the cytosol, mitochondria, endoplasmic reticulum, and nucleus, each exhibiting distinct regulatory mechanisms. Perturbations in GSH dynamics contribute to pathophysiological conditions, emphasizing the clinical significance of understanding its intricate regulation. This review consolidates current knowledge on subcellular GSH dynamics, highlighting its implications in drug development, particularly in covalent drug design and antitumor strategies targeting intracellular GSH levels. Challenges and future directions in deciphering subcellular GSH dynamics are discussed, advocating for innovative methodologies to advance our comprehension and facilitate the development of precise therapeutic interventions based on GSH modulation.Copyright © 2024 Elsevier Ltd. All rights reserved.