本期《生物医学杂志》重点介绍了药物递送方面的重大进展，包括适体功能化脂质体和纳米酶。一种新的生物标志物组合有望改善特发性肺纤维化的诊断。间充质干细胞被认为可以减轻系统性红斑狼疮的炎症，并且由普遍的 mRNA 修饰驱动的潜在正反馈回路被认为可以促进 NSCLC 的进展。其他文章探讨了导致肌肉功能障碍的自噬的病理学影响、孤儿药与胶质母细胞瘤患者标准治疗相结合的益处，以及转录超级增强子对早期食管鳞状细胞癌的影响。最后，本期深入了解不同芽囊菌亚型的作用，以及使用激光治疗婴儿血管瘤。版权所有 © 2024 作者。由 Elsevier B.V. 出版。保留所有权利。

This issue of the Biomedical Journal highlights major advancements in drug delivery, including aptamer-functionalized liposomes and nanozymes. A new biomarker combination shows promise for improved diagnosis of idiopathic pulmonary fibrosis. Mesenchymal stem cells are suggested to mitigate inflammation in systemic lupus erythematosus, and a potential positive feedback loop driven by a prevalent mRNA modification is suggested to enhance NSCLC progression. Additional articles explore a pathological impact on autophagy leading to muscle dysfunction, the benefits of integrating an orphan drug with standard therapy for glioblastoma patients, and the influence of transcriptional super-enhancers in early-stage esophageal squamous cell carcinoma. Finally, this issue provides insights into the roles of different Blastocystis subtypes, and the use of laser light for treating infantile hemangioma.Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.