遍布所有人体器官和血液的骨髓细胞是一类多功能的先天免疫细胞。它们对于感知和调节组织稳态和炎症等多种过程至关重要，并且通常以其在调节或促进炎症中的作用为特征。最近对培养细胞和小鼠模型的研究强调了铁在扭曲骨髓细胞在组织损伤和修复中的功能特性中的作用。在这里，我们回顾了一些关于铁如何在其摄取、储存和代谢的背景下影响和决定骨髓细胞极化的新兴概念，包括在多发性硬化症 (MS)、镰状细胞病和肿瘤等疾病中。版权所有 © 2024作者。由爱思唯尔有限公司出版。保留所有权利。

Myeloid cells that populate all human organs and blood are a versatile class of innate immune cells. They are crucial for sensing and regulating processes as diverse as tissue homeostasis and inflammation and are frequently characterized by their roles in either regulating or promoting inflammation. Recent studies in cultured cells and mouse models highlight the role of iron in skewing the functional properties of myeloid cells in tissue damage and repair. Here, we review certain emerging concepts on how iron influences and determines myeloid cell polarization in the context of its uptake, storage, and metabolism, including in conditions such as multiple sclerosis (MS), sickle cell disease, and tumors.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.