石榴籽（PS）是从石榴果实中提取的干燥种子，约占果实总重量的20%，是石榴汁提取的副产品。这些种子在维吾尔族和藏族文化中的传统医学中具有重要意义，在中医中具有多种临床应用。这些应用包括治疗胃寒胃酸、腹胀、肝胆发热和小儿肠炎。 PS具有健胃、理气、镇痛和抗炎作用等特性。广泛的研究强调了PS在各种植物化学化合物和代谢物中的丰富性，特别是不饱和脂肪酸（特别是亚麻酸和亚油酸）、酚类化合物生育酚、蛋白质和挥发油。值得注意的是，在这些生物活性化合物中，PS 中发现的石榴酸 (PA) 在预防和治疗癌症、糖尿病、肥胖症和其他疾病方面具有潜力。尽管有大量关于石榴作为植物实体的文献，但专门针对 PS 的化学成分和药理作用的全面综述仍然难以捉摸。因此，本文旨在巩固对PS药用特性的认识，总结其化学成分、传统用途以及治疗多种疾病的药理作用，为PS在药理学领域的进步和应用奠定基础。版权所有© 2024 王、孙、余、王、崔。

Pomegranate seeds (PS) are the dried seeds derived from pomegranate fruit, accounting for approximately 20% of the fruit's total weight, and are a by-product of pomegranate juice extraction. These seeds hold significance in traditional medicine among Uyghurs and Tibetan cultures, featuring diverse clinical applications within traditional Chinese medicine. These applications include management of gastric coldness and acidity, abdominal distension, liver and gallbladder fever, and pediatric enteritis. PS demonstrates properties such as stomach tonicity, qi regulation, analgesia, and anti-inflammatory effects. Extensive research underscores the richness of PS in various phytochemical compounds and metabolites, notably unsaturated fatty acids (particularly linolenic acid and linoleic acid), phenolic compounds tocopherols, proteins, and volatile oils. Notably, among these bioactive compounds, punicic acid (PA), found within PS, demonstrates potential in the prevention and treatment of cancers, diabetes, obesity, and other ailments. Despite extensive literature on pomegranate as a botanical entity, a comprehensive review focusing specifically on the chemical composition and pharmacological effects of PS remains elusive. Therefore, this review aimed to consolidate knowledge regarding the medicinal properties of PS, summarizing its chemical composition, traditional uses, and pharmacological effects in treating various diseases, thereby laying a foundation for the advancement and application of PS in the field of pharmacology.Copyright © 2024 Wang, Sun, Yu, Wang and Cui.