内源性形成或从饮食中外源获得的晚期糖基化终产物 (AGE) 可能会导致慢性炎症、细胞内信号传导改变以及包括结直肠癌 (CRC) 在内的多种慢性疾病的发病机制。然而，AGEs 在 CRC 存活中的作用却鲜为人知。在欧洲癌症与营养前瞻性调查 (EPIC) 研究中，使用多变量调整的 Cox 比例风险回归对 1369 例 CRC 病例中的诊断前循环 AGE 及其可溶性受体 (sRAGE) 与 CRC 特异性死亡率和总体死亡率之间的关联进行了评估。主要血浆 AGE、Nε-[羧甲基]赖氨酸 (CML)、Nε-[羧乙基]赖氨酸 (CEL) 和 Nδ-[5-氢-5-甲基-4-咪唑啉-2-基]- 的浓度使用超高效液相色谱质谱法测量鸟氨酸（MG-H1）。通过酶联免疫吸附测定评估 sRAGE。在平均 96 个月的随访期内，有 693 人死亡，其中 541 人死于结直肠癌。个体和组合 AGE 与 CRC 特异性或总体死亡率没有统计学显着相关性。然而，CEL 可能存在性别间的相互作用（Pinteraction = .05）。 sRAGE 较高的参与者死于 CRC (HRQ5vs.Q1 = 1.67, 95% CI: 1.21-2.30, Ptrend = .02) 或任何原因 (HRQ5vs.Q1 = 1.38, 95% CI: 1.05-1.83, P趋势 = .09)。这些关联在 CRC 诊断前患有糖尿病 (Pinteraction = .03) 和糖尿病前期 (Pinteraction <.01) 的病例中往往更强。诊断前 AGE 与 CRC 患者的 CRC 特异性死亡率和总体死亡率无关。然而，观察到 sRAGE 呈正相关。我们的研究结果可能会激发对 AGE 和 sRAGE 在癌症患者生存中的作用的进一步研究，特别强调性别和糖尿病的潜在影响改变。© 2024 UICC。

Advanced glycation end-products (AGEs), formed endogenously or obtained exogenously from diet, may contribute to chronic inflammation, intracellular signaling alterations, and pathogenesis of several chronic diseases including colorectal cancer (CRC). However, the role of AGEs in CRC survival is less known. The associations of pre-diagnostic circulating AGEs and their soluble receptor (sRAGE) with CRC-specific and overall mortality were estimated using multivariable-adjusted Cox proportional hazards regression among 1369 CRC cases in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Concentrations of major plasma AGEs, Nε-[carboxy-methyl]lysine (CML), Nε-[carboxy-ethyl]lysine (CEL) and Nδ-[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine (MG-H1), were measured using ultra-performance liquid chromatography mass-spectrometry. sRAGE was assessed by enzyme-linked immunosorbent assay. Over a mean follow-up period of 96 months, 693 deaths occurred of which 541 were due to CRC. Individual and combined AGEs were not statistically significantly associated with CRC-specific or overall mortality. However, there was a possible interaction by sex for CEL (Pinteraction = .05). Participants with higher sRAGE had a higher risk of dying from CRC (HRQ5vs.Q1 = 1.67, 95% CI: 1.21-2.30, Ptrend = .02) or any cause (HRQ5vs.Q1 = 1.38, 95% CI: 1.05-1.83, Ptrend = .09). These associations tended to be stronger among cases with diabetes (Pinteraction = .03) and pre-diabetes (Pinteraction <.01) before CRC diagnosis. Pre-diagnostic AGEs were not associated with CRC-specific and overall mortality in individuals with CRC. However, a positive association was observed for sRAGE. Our findings may stimulate further research on the role of AGEs and sRAGE in survival among cancer patients with special emphasis on potential effect modifications by sex and diabetes.© 2024 UICC.