CAR T 细胞联合疗法治疗癌症。
CAR T cell combination therapies to treat cancer.
发表日期：2024 Aug 12
作者：
Ugur Uslu, Sofia Castelli, Carl H June
来源：
CANCER CELL
摘要：
嵌合抗原受体 (CAR) T 细胞可有效用于某些血液恶性肿瘤，但肿瘤复发和实体瘤治疗成功率仍然有限。最近的努力重点是开发联合治疗以提高疗效和安全性。在这里，我们对此类组合方法进行了全面概述，并考虑了正在进行的临床试验。版权所有 © 2024 Elsevier Inc. 保留所有权利。
Chimeric antigen receptor (CAR) T cells are effectively used in certain hematological malignancies, though tumor relapse and limited success in solid tumors persist. Recent efforts focus on developing combination treatments to enhance outcomes and safety. Here, we provide a comprehensive overview of such combinatorial approaches and a consideration of ongoing clinical trials.Copyright © 2024 Elsevier Inc. All rights reserved.