转座元件（TE）是真核基因组的重要组成部分，并受到严格的监管机制以避免其潜在的有害影响。然而，大量研究已经证实了 TE，特别是长散布核元件 1 (LINE-1) 在植入前发育、衰老、癌症和其他与年龄相关的疾病过程中的复活。 LINE-1 家族还与多种衰老相关过程有关，包括基因组不稳定、异染色质丢失、DNA 甲基化和衰老相关分泌表型 (SASP)。此外，LINE-1家族在癌症发展中的作用也得到证实。该领域的研究为 LINE-1 活性的功能机制提供了宝贵的见解，增强了我们对衰老调节的理解。本综述全面总结了 LINE-1 的最新研究结果及其在衰老和年龄相关疾病中的作用。版权所有 © 2024 Elsevier B.V. 保留所有权利。

Transposable elements (TEs) are essential components of eukaryotic genomes and are subject to stringent regulatory mechanisms to avoid their potentially deleterious effects. However, numerous studies have verified the resurrection of TEs, particularly long interspersed nuclear element-1 (LINE-1), during preimplantation development, aging, cancer, and other age-related diseases. The LINE-1 family has also been implicated in several aging-related processes, including genomic instability, loss of heterochromatin, DNA methylation, and the senescence-associated secretory phenotype (SASP). Additionally, the role of the LINE-1 family in cancer development has also been substantiated. Research in this field has offered valuable insights into the functional mechanisms underlying LINE-1 activity, enhancing our understanding of aging regulation. This review provides a comprehensive summary of current findings on LINE-1 and their roles in aging and age-related diseases.Copyright © 2024 Elsevier B.V. All rights reserved.