不对称细胞分裂（ACD）在发育、组织稳态和干细胞维持中发挥着关键作用。新的证据表明，长非编码 RNA (lncRNA) 是 ACD 的关键调节因子，协调着控制细胞命运决定的复杂分子机制。本综述总结了当前的文献，以阐明 lncRNA 在跨不同生物环境调节 ACD 中的不同作用。探讨了 lncRNA 介导的不对称细胞分裂的调控机制，包括它们与蛋白质效应子的相互作用、表观遗传调控和亚细胞定位。此外，我们还讨论了失调的 lncRNA 在介导导致肿瘤发生的 ACD 中的影响。通过整合不同实验模型和细胞类型的研究结果，这篇综述深入了解了 lncRNA 在控制不对称细胞分裂中的多方面作用，揭示了基本的生物过程。该领域的进一步研究可能会导致针对失调的 lncRNA 的新疗法的开发，以恢复正常的细胞分裂和功能。通过靶向参与 ACD 的特定 lncRNA，调节 ACD 的 lncRNA 知识可能会彻底改变再生医学和癌症治疗领域。通过揭示 lncRNA 和细胞过程之间复杂的相互作用，可能会发现精准医学方法的潜在新机遇。版权所有 © 2024 作者。由 Elsevier B.V. 出版。保留所有权利。

Asymmetric cell division (ACD) plays a pivotal role in development, tissue homeostasis, and stem cell maintenance. Emerging evidence suggests that long non-coding RNAs (lncRNAs) are key regulators of ACD, orchestrating the intricate molecular machinery that governs cell fate determination. This review summarizes current literature to elucidate the diverse roles of lncRNAs in modulating ACD across various biological contexts. The regulatory mechanisms of asymmetric cell division mediated by lncRNAs, including their interactions with protein effectors, epigenetic regulation, and subcellular localization are explored. Additionally, we discuss the implications of dysregulated lncRNAs in mediating ACD that lead to tumorigenesis. By integrating findings from diverse experimental models and cell types, this review provides insights into the multifaceted roles of lncRNAs in governing asymmetric cell division, shedding light on fundamental biological processes. Further research in this area may lead to the development of novel therapies targeting dysregulated lncRNAs to restore proper cell division and function. The knowledge of lncRNAs regulating ACD could potentially revolutionize the field of regenerative medicine and cancer therapy by targeting specific lncRNAs involved in ACD. By unraveling the complex interactions between lncRNAs and cellular processes, the potential novel opportunities for precision medicine approaches may be uncovered.Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.