电压门控钠通道 (VGSC) 在可电兴奋的细胞和组织中启动动作电位。令人惊讶的是，一些 VGSC 基因在多种癌症中异常表达，这些基因源自不产生经典动作电位的“非兴奋”组织，显示出作为癌症有希望的药理学靶点的潜力。之前关于该主题的大多数综述文章范围有限，很大程度上无法让研究人员全面了解 VGSC 在癌症中的作用。在这里，我们回顾了所有九个 VGSC α 亚基基因 (SCN1A-11A) 及其四个调节 β 亚基基因 (SCN1B-4B) 的表达模式。我们回顾了癌症基因组图谱 (TCGA) 数据库的数据，并对已发表的论文进行了广泛的检索。我们总结和回顾了之前的独立研究，并分析了 TCGA 数据库中的 VGSC 基因，了解 VGSC 对癌症的潜在影响。对从独立研究和数据审查中收集的证据进行比较，以审查先前研究中的潜在偏差，并为未来的研究方向提供见解。该综述支持这样的观点，即 VGSC 在某些癌症类型（如乳腺癌、结肠癌、前列腺癌和肺癌）的诊断和治疗中发挥着重要作用。本文概述了癌症中电压门控钠通道的当前知识，以及进一步研究的潜在途径。虽然需要进一步的研究来充分了解 VGSC 在癌症中的作用，但 VGSC 在临床诊断和治疗方面的潜力是有前景的。© 2024。作者。

Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from "non-excitable" tissues that do not generate classic action potentials, showing potential as a promising pharmacological target for cancer. Most of the previous review articles on this topic are limited in scope, and largely unable to provide researchers with a comprehensive understanding of the role of VGSC in cancers. Here, we review the expression patterns of all nine VGSC α-subunit genes (SCN1A-11A) and their four regulatory β-subunit genes (SCN1B-4B). We reviewed data from the Cancer Genome Atlas (TCGA) database, complemented by an extensive search of the published papers. We summarized and reviewed previous independent studies and analyzed the VGSC genes in the TCGA database regarding the potential impact of VGSC on cancers. A comparison between evidence gathered from independent studies and data review was performed to scrutinize potential biases in prior research and provide insights into future research directions. The review supports the view that VGSCs play an important role in diagnostics as well as therapeutics of some cancer types, such as breast, colon, prostate, and lung cancer. This paper provides an overview of the current knowledge on voltage-gated sodium channels in cancer, as well as potential avenues for further research. While further research is required to fully understand the role of VGSCs in cancer, the potential of VGSCs for clinical diagnosis and treatment is promising.© 2024. The Author(s).