变构药物是有利的。然而，他们仍然面临障碍，包括识别将有效改变活性位点的变构位点。目前的策略主要集中于识别远离活性位点的口袋，变构配体将停靠在其中，并且没有准确地解释活性位点是如何改变的。有利的变构抑制剂停靠在活性位点附近的位点并遵循自然，模仿不同的变构调节策略。以下文章强调了变构在药物设计中的巨大意义，描述了当前的变构策略，特别提供了未来的方向。文章最后提出了作者对该主题的专家观点。为了选择变构抑制剂开发的富有成效的场所，我们应该向大自然学习。目前，有用的策略遵循这条路线。例如，考虑用于缓解自抑制和利用变构降解剂的机制。模仿补偿性或拯救性突变也可能属于这样的论点，就像捕获支架蛋白特征的分子胶一样。捕捉自然并创造性地定制其模仿可以继续创新变构药物的发现。

Allosteric drugs are advantageous. However, they still face hurdles, including identification of allosteric sites that will effectively alter the active site. Current strategies largely focus on identifying pockets away from the active sites into which the allosteric ligand will dock and do not account for exactly how the active site is altered. Favorable allosteric inhibitors dock into sites that are nearby the active sites and follow nature, mimicking diverse allosteric regulation strategies.The following article underscores the immense significance of allostery in drug design, describes current allosteric strategies, and especially offers a direction going forward. The article concludes with the authors' expert perspectives on the subject.To select a productive venue in allosteric inhibitor development, we should learn from nature. Currently, useful strategies follow this route. Consider, for example, the mechanisms exploited in relieving autoinhibition and in harnessing allosteric degraders. Mimicking compensatory, or rescue mutations may also fall into such a thesis, as can molecular glues that capture features of scaffolding proteins. Capturing nature and creatively tailoring its mimicry can continue to innovate allosteric drug discovery.