主要目的是评估腹腔镜下畸胎瘤生长综合征女性保留生育力手术的可行性。回顾性队列研究。中国三级甲等医院。2015年1月至2023年8月期间接受保留生育手术的畸胎瘤生长综合征患者。基线特征并评估手术结果，包括临床信息、手术程序、手术时间、术中失血量、并发症、住院时间和随访信息。 26 例卵巢生长性畸胎瘤综合征患者接受了保留生育能力手术：12 例腹腔镜手术，14 例接受开腹手术。在腹腔镜组中，初次治疗未成熟畸胎瘤或混合性卵巢恶性生殖细胞肿瘤的患者中位年龄为14.0岁（四分位距：13.0-24.5岁）。 11名患者未生育。原发性卵巢肿瘤10例为纯性未成熟畸胎瘤，2例为混合性卵巢生殖细胞瘤。 11例患者完成腹腔镜肿瘤切除。腹腔镜组患者的中位手术时间较短（76.5 分钟 vs 180.0 分钟，p=0.001），估计失血量较低（20.0 vs 400.0 ml，p < 0.001），术后住院时间缩短（2.0 天 vs 7.0 天，p < 0.001），与剖腹手术相比。没有中转剖腹手术，也没有围手术期并发症。组织学检查证实所有病例均为成熟畸胎瘤。在中位随访 21.9 个月（四分位距：7.6-44.9 个月）期间，11 名患者无病存活，1 名患病存活。术后实现了一次妊娠。对于精心挑选的卵巢生长性畸胎瘤综合征患者，腹腔镜保留生育力手术可能是一种可行的选择。手术应由经过内窥镜手术培训的经验丰富的工作人员在妇科肿瘤中心进行。需要更多的研究和长期随访来确定该人群腹腔镜手术的肿瘤学结果和安全性。版权所有 © 2024。由 Elsevier Inc. 出版。

The main objective is to evaluate the feasibility of laparoscopic fertility-sparing surgery in women with growing teratoma syndrome.Retrospective cohort study.Chinese tertiary university hospital.Patients with growing teratoma syndrome who underwent fertility-sparing surgery between January 2015 and August 2023.Baseline characteristics and surgical outcomes were evaluated, including clinical information, surgical procedures, operative time, intraoperative blood loss, complications, length of hospital stay, and follow-up information.Twenty-six patients with ovarian growing teratoma syndrome underwent fertility-sparing surgery: 12 had laparoscopic surgery and 14 underwent laparotomic surgery. In the laparoscopic group, the median age of the patients during initial management of immature teratoma or mixed malignant ovarian germ cell tumor was 14.0 years (interquartile range: 13.0-24.5 years). Eleven patients were nulliparous. The primary ovarian tumor was pure immature teratoma in 10 patients and mixed ovarian germ cell tumor in 2 patients. Complete laparoscopic tumor resection was achieved in 11 patients. Patients in laparoscopic group had shorter median operative time (76.5 vs 180.0 minutes, p = 0.001), lower estimated blood loss (20.0 vs 400.0 ml, p < 0.001), decreased postoperative hospital stay (2.0 vs 7.0 days, p < 0.001), compared with laparotomic surgery. There was no conversion to laparotomy and no perioperative complications. Histological examination confirmed mature teratoma in all cases. During a median follow-up of 21.9 months (interquartile range: 7.6-44.9 months), 11 patients were alive without disease and 1 was alive with disease. One pregnancy was achieved postoperatively.Laparoscopic fertility-sparing surgery may represent a feasible option in well-selected patients with ovarian growing teratoma syndrome. Surgery should be performed in gynecologic oncology centers by experienced staff trained in endoscopic procedures. More research and long-time follow-up are needed to determine the oncological outcomes and safety of laparoscopic surgery in this population.Copyright © 2024. Published by Elsevier Inc.