这项研究深入探讨了下咽鳞状细胞癌 (HSCC) 的分子复杂性，特别关注 ETS 易位变体 4 (ETV4) 在有氧糖酵解中发挥的关键作用。目的是发现HSCC早期诊断和治疗的新靶点。严格检查了 HSCC 组织中的 ETV4 表达，揭示了其与患者生存的关系。通过综合实验，我们证明ETV4激活促进HSCC细胞增殖和侵袭，同时抑制细胞凋亡。此外，体内实验证实了ETV4激活的促肿瘤作用。该研究阐明了 ETV4 与 NSUN2 启动子的结合及其对 PKM2 表达的影响，从而调节 HSCC 中的糖酵解和细胞功能。© 作者 2024。由牛津大学出版社出版。版权所有。如需权限，请发送电子邮件至：journals.permissions@oup.com。

This study delves into the molecular intricacies of hypopharyngeal squamous cell carcinoma (HSCC), specifically focusing on the pivotal role played by ETS translocation variant 4 (ETV4) in aerobic glycolysis. The objective is to uncover new targets for early diagnosis and treatment of HSCC. ETV4 expression in HSCC tissues was rigorously examined, revealing its association with patient survival. Through comprehensive experimentation, we demonstrated that ETV4 activation promotes HSCC cell proliferation and invasion while inhibiting apoptosis. Furthermore, in vivo experiments confirmed the tumor-promoting effect of ETV4 activation. The study elucidated the binding of ETV4 to the NSUN2 promoter and its influence on PKM2 expression, thereby regulating glycolysis and cellular functions in HSCC.© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.