慢性阻塞性肺病（COPD）和肺癌的并发已被肺科医生和肿瘤学家广泛报道和广泛讨论。然而，大多数研究都集中在共同的风险因素、DNA 损伤途径、免疫微环境、炎症和不平衡的蛋白酶/抗蛋白酶上。在本综述中，我们从气道多能细胞命运决定方面探讨了慢性阻塞性肺病与肺癌之间的关联，并讨论了参与维持肺上皮稳态的各种细胞类型和信号通路，以及它们在同时发生的发病机制中的作用慢性阻塞性肺病（COPD）和肺癌。

The concurrence of chronic obstructive pulmonary disease (COPD) and lung cancer has been widely reported and extensively addressed by pulmonologists and oncologists. However, most studies have focused on shared risk factors, DNA damage pathways, immune microenvironments, inflammation, and imbalanced proteases/antiproteases. In the present review, we explored the association between COPD and lung cancer in terms of airway pluripotent cell fate determination and discussed the various cell types and signaling pathways involved in the maintenance of lung epithelium homeostasis, and their involvement in the pathogenesis of co-occurrence of COPD and lung cancer.