既往研究调查了癌症患者的心血管疾病（CVD）风险，但对成人和青少年（AYA）胃癌幸存者的CVD风险了解有限。本研究旨在调查AYA胃癌幸存者的CVD发生率，通过治疗类型进行分析并确定相关的风险因素。我们使用韩国国民健康保险局 2006 年至 2019 年收集的数据进行了一项回顾性队列研究。使用变量年龄、年龄、性别、收入、居住区域和是否存在合并症，我们将参与者分为胃癌组 (n = 6562) 和非癌症对照组 (n = 19,678)。 Cox 回归模型用于计算 CVD 发病率的风险比 (HR)。该研究通过癌症治疗评估了 CVD 发生率，并通过多变量 Cox 回归确定了危险因素。在中位 6.5 年的随访期间，AYA 胃癌幸存者始终表现出较高的 CVD 发生率。与对照组相比，他们的 CVD 风险显着升高（HR，1.18；95% 置信区间 [CI] 1.05-1.33）。特别是，深静脉血栓形成（HR，3.93；95% CI 3.06-14.67）和肺栓塞（HR，6.58；95% CI 3.06-14.67）风险显着增加。化疗与中风、心力衰竭、心房颤动、深静脉血栓和肺栓塞的风险增加相关。高血压（HR，1.58；95% CI 1.10-2.26）和血脂异常（HR，1.46；95% CI 1.06-2.20）成为 CVD 发展的危险因素。这项研究报告了 AYA 胃癌幸存者 CVD 风险升高，并强调了需要对这一人群的 CVD 进行警惕监测。© 2024。作者。

Previous studies have investigated cardiovascular disease (CVD) risks in cancer patients, but there is limited knowledge concerning the CVD risk in adult and young adolescent (AYA) survivors of gastric cancer.This study aims to investigate the incidence of CVD in AYA gastric cancer survivors, analyzing it by treatment type and identifying associated risk factors.We conducted a retrospective cohort study using Korean National Health Insurance Service data collected from 2006 to 2019. Propensity score matching (1:3, caliper < 0.1) was performed using the variables age, sex, income, residential area, and presence of comorbidities, and we classified participants into gastric cancer (n = 6562) and non-cancer control (n = 19,678) groups. Cox regression models were used to calculate hazard ratios (HRs) for CVD incidence. The study assessed CVD incidence by cancer treatment and identified risk factors through multivariable Cox regression.During a median 6.5-year follow-up, AYA gastric cancer survivors consistently exhibited greater CVD incidence. Their risk of CVD was significantly elevated compared to that of controls (HR, 1.18; 95% confidence interval [CI] 1.05-1.33). In particular, deep vein thrombosis (HR, 3.93; 95% CI 3.06-14.67) and pulmonary embolism (HR, 6.58; 95% CI 3.06-14.67) risks were notably increased. Chemotherapy was associated with an increased risk of stroke, heart failure, atrial fibrillation, deep vein thrombosis, and pulmonary embolism. Hypertension (HR, 1.58; 95% CI 1.10-2.26) and dyslipidemia (HR, 1.46; 95% CI 1.06-2.20) emerged as risk factors for CVD development.This study reports elevated risks of CVD in AYA gastric cancer survivors and emphasizes the need for vigilant monitoring of CVD in this population.© 2024. The Author(s).