细胞外陷阱（ET）是先天免疫防御的一种特殊形式，其中白细胞释放由染色质和活性蛋白组成的 ET 以消除病原微生物。除了ETs的抗感染作用外，研究人员还发现它们参与炎症性疾病、肿瘤、自身免疫性疾病和过敏性疾病的发病机制。哮喘是一种涉及多种免疫细胞的慢性气道炎症性疾病。哮喘患者 ET 水平升高表明 ET 在哮喘发病机制中发挥重要作用。我们在此综述中性粒细胞、嗜酸性粒细胞和巨噬细胞释放的 ET 在哮喘中的形成机制、作用和治疗策略的研究工作。© 2024。作者。

Extracellular traps (ETs) are a specialized form of innate immune defense in which leukocytes release ETs composed of chromatin and active proteins to eliminate pathogenic microorganisms. In addition to the anti-infection effect of ETs, researchers have also discovered their involvement in the pathogenesis of inflammatory disease, tumors, autoimmune disease, and allergic disease. Asthma is a chronic airway inflammatory disease involving multiple immune cells. The increased level of ETs in asthma patients suggests that ETs play an important role in the pathogenesis of asthma. Here we review the research work on the formation mechanism, roles, and therapeutic strategies of ETs released by neutrophils, eosinophils, and macrophages in asthma.© 2024. The Author(s).