通过血液和电子流重新审视瓦尔堡效应。
The Warburg Effect Revisited through Blood and Electron Flow.
发表日期：2024 Jul 02
作者：
Yahui Wang, Chi V Dang
来源：
CANCER RESEARCH
摘要：
瓦伯格效应描述了许多癌症在有氧的情况下大量消耗葡萄糖并将其转化为乳酸的倾向。瓦尔堡效应对癌细胞的好处仍然是个谜，特别是因为细胞外处理不完全氧化的乳酸是一种浪费。然而，乳酸盐不会从体内被丢弃，而是以丙酮酸的形式回收，通过氧化组织和细胞中的三羧酸循环进行代谢。因此，组织和器官间代谢在肿瘤代谢中发挥着重要作用。肿瘤乳酸的产生在其他地方再循环，与科里循环平行，在科里循环中，肌肉活动产生的乳酸被输送到肝脏，在那里转化为丙酮酸，随后作为葡萄糖部分储存在糖原中。这个观点将在讨论葡萄糖如何在肿瘤中使用时考虑这种有机体背景。我们重点介绍几十年前在《癌症研究》杂志上发表的几篇重要文章，这些文章是我们当前对癌症生物学和新陈代谢的理解的基础。©2024 美国癌症研究协会。
The Warburg effect describes the propensity of many cancers to consume glucose avidly and convert it to lactate in the presence of oxygen. The benefit of the Warburg effect on cancer cells remains enigmatic, particularly because extracellular disposal of incompletely oxidized lactate is wasteful. However, lactate is not discarded from the body, but rather recycled as pyruvate for metabolism through the tricarboxylic acid cycle in oxidative tissues and cells. Hence, tissue and interorgan metabolism play important roles in tumor metabolism. The production of tumor lactate to be recycled elsewhere parallels the Cori cycle, in which lactate produced by muscle activity is shuttled to the liver, where it is converted to pyruvate and subsequently stored as glucose moieties in glycogen. This perspective will consider this organismal contextwhile discussing how glucose is used in tumors. We highlight several key articles published decades ago in Cancer Research that are foundational to our current understanding of cancer biology and metabolism.©2024 American Association for Cancer Research.