本研究旨在调查接受保留生育手术 (FSS) 治疗卵巢癌 (OC) 或卵巢癌 (OC) 的育龄妇女的健康相关生活质量 (HRQoL)、性功能、心理健康、生殖问题和生育结果。卵巢交界性肿瘤 (BOT)，为期 2 年。前瞻性纵向多中心研究，包括 2016 年至 2018 年在瑞典接受 FSS 的 18-40 岁女性。收集了诊断时的临床数据、组织病理学结果以及有关肿瘤和生殖结果的 2 年随访数据。参与者在诊断时以及 FSS 后一年和两年时完成了 EORTC QLQ-C30 和 OV-28、FSFI、HADS 和研究特定项目。使用重复测量模型分析数据，以调查随时间的变化。在 68 名符合条件的女性中，有 49 名因良性病理或随后的根治性手术而被排除。在平均 20.5 个月的随访期间，两名女性出现复发，82% 的女性报告月经规律。大多数人（94%）有成为亲生母亲的强烈愿望，这种愿望随着时间的推移一直存在或增强。受孕率为76%。随着时间的推移，HRQoL、心理健康和性功能得到改善，患有性功能障碍的女性比例有所下降。在一年的随访中，50% 的未生育女性的评分表明性功能障碍，而在手术前或手术后生育的女性中这一比例为 0% (p = 0.008)。 HRQoL、心理健康和性功能在两年内得到改善对患有 OC 或 BOT 的年轻女性进行 FSS 后一年的随访。与未产妇相比，在 FSS 之前或之后生育的女性报告性功能有所改善。版权所有 © 2024 作者。由爱思唯尔公司出版。保留所有权利。

This study aimed to investigate health-related quality of life (HRQoL), sexual function, psychological-health, reproductive concerns, and fertility outcomes of women of reproductive age undergoing Fertility-Sparing Surgery (FSS) for treatment of ovarian cancer (OC) or borderline ovarian tumor (BOT), over a 2-year period.Prospective longitudinal multicentre study including women 18-40 years undergoing FSS between 2016 and 2018 in Sweden. Clinical data at diagnosis, histopathological findings and 2-year follow-up regarding oncological and reproductive outcomes were collected. Participants completed the EORTC QLQ-C30 and OV-28, FSFI, HADS and study-specific items at time of diagnosis and at one- and two-years following FSS. Data were analysed using a model for repeated measures to investigate changes over time.Of 68 eligible women, 49 were included following exclusions due to benign pathology or subsequent radical surgery. During a mean follow-up of 20.5 months, two women experienced a recurrence and 82% reported regular menstruations. The majority (94%) had a strong desire to become biological mothers, which remained or increased over time. The conception-rate was 76%. HRQoL, psychological-health and sexual function improved over time and the proportion of women with sexual dysfunction decreased. At one-year follow-up 50% of nulliparous women had scores indicating sexual dysfunction compared to 0% of the women who had given birth either before or after surgery (p = 0.008).HRQoL, psychological-health and sexual function improved during two-year follow-up after FSS in young women presenting with OC or BOT. Women who had given birth prior to or after FSS reported improved sexual function compared to nulliparous women.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.