免疫细胞膜衍生的仿生纳米药物递送系统：肿瘤免疫疗法的开创性平台
Immunocyte membrane-derived biomimetic nano-drug delivery system: a pioneering platform for tumour immunotherapy
影响因子:8.40000
分区:医学2区 / 药学1区 化学：综合2区
发表日期:2024 Dec
作者:
Yuan-Ye Zeng, Qing Gu, Dan Li, Ai-Xue Li, Rong-Mei Liu, Jian-Ying Liang, Ji-Yong Liu
摘要
肿瘤免疫疗法以其高特异性和最小的副作用为特征，在癌症治疗领域取得了革命性的进步。但是，肿瘤免疫微环境（时间）的复杂机制和患者免疫系统的个体变异性仍然对其临床应用构成重大挑战。免疫细胞膜涂层的纳米载体系统作为创新的仿生药物输送平台，由于其高靶向能力，良好的生物相容性和低免疫原性，因此在肿瘤免疫疗法方面具有显着的优势。在这篇综述中，我们总结了基于肿瘤免疫疗法的免疫细胞的仿生递送系统的最新研究进展。我们概述了现有的肿瘤免疫疗法方法，包括免疫检查点疗法，收养细胞转移治疗和癌症疫苗等，重点是在肿瘤免疫疗法中应用各种免疫细胞膜及其在药物递送和免疫调节中的前景和挑战。我们期待进一步探索基于免疫细胞膜涂层纳米颗粒的仿生递送系统的应用，旨在为肿瘤免疫的临床治疗提供新的框架。
Abstract
Tumor immunotherapy characterized by its high specificity and minimal side effects has achieved revolutionary progress in the field of cancer treatment. However, the complex mechanisms of tumor immune microenvironment (TIME) and the individual variability of patients' immune system still present significant challenges to its clinical application. Immunocyte membrane-coated nanocarrier systems, as an innovative biomimetic drug delivery platform, exhibit remarkable advantages in tumor immunotherapy due to their high targeting capability, good biocompatibility and low immunogenicity. In this review we summarize the latest research advances in biomimetic delivery systems based on immune cells for tumor immunotherapy. We outline the existing methods of tumor immunotherapy including immune checkpoint therapy, adoptive cell transfer therapy and cancer vaccines etc. with a focus on the application of various immunocyte membranes in tumor immunotherapy and their prospects and challenges in drug delivery and immune modulation. We look forward to further exploring the application of biomimetic delivery systems based on immunocyte membrane-coated nanoparticles, aiming to provide a new framework for the clinical treatment of tumor immunity.