免疫细胞膜衍生仿生纳米药物递送系统：肿瘤免疫治疗的开创性平台
Immunocyte membrane-derived biomimetic nano-drug delivery system: a pioneering platform for tumour immunotherapy
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影响因子:8.4
分区:医学2区 / 药学1区 化学：综合2区
发表日期:2024 Dec
作者:
Yuan-Ye Zeng, Qing Gu, Dan Li, Ai-Xue Li, Rong-Mei Liu, Jian-Ying Liang, Ji-Yong Liu
DOI:
10.1038/s41401-024-01355-z
摘要
肿瘤免疫治疗以其高特异性和副作用少的特点，在癌症治疗领域取得了革命性进展。然而，肿瘤免疫微环境（TIME）的复杂机制及患者免疫系统的个体差异仍是其临床应用的重大挑战。免疫细胞膜包覆的纳米载体系统，作为一种创新的仿生药物递送平台，因其高靶向能力、良好的生物相容性和低免疫原性，在肿瘤免疫治疗中展现出显著优势。本文总结了基于免疫细胞的仿生递送系统在肿瘤免疫治疗中的最新研究进展。我们概述了包括免疫检查点治疗、细胞免疫治疗和癌症疫苗等现有的肿瘤免疫治疗方法，重点介绍了各种免疫细胞膜在肿瘤免疫中的应用，以及它们在药物递送和免疫调节中的前景与挑战。期待进一步探索基于免疫细胞膜包覆纳米粒子的仿生递送系统的应用，为临床肿瘤免疫治疗提供新的框架。
Abstract
Tumor immunotherapy characterized by its high specificity and minimal side effects has achieved revolutionary progress in the field of cancer treatment. However, the complex mechanisms of tumor immune microenvironment (TIME) and the individual variability of patients' immune system still present significant challenges to its clinical application. Immunocyte membrane-coated nanocarrier systems, as an innovative biomimetic drug delivery platform, exhibit remarkable advantages in tumor immunotherapy due to their high targeting capability, good biocompatibility and low immunogenicity. In this review we summarize the latest research advances in biomimetic delivery systems based on immune cells for tumor immunotherapy. We outline the existing methods of tumor immunotherapy including immune checkpoint therapy, adoptive cell transfer therapy and cancer vaccines etc. with a focus on the application of various immunocyte membranes in tumor immunotherapy and their prospects and challenges in drug delivery and immune modulation. We look forward to further exploring the application of biomimetic delivery systems based on immunocyte membrane-coated nanoparticles, aiming to provide a new framework for the clinical treatment of tumor immunity.