旨在调查加速度计测量的特定强度体力活动 (PA) 与心血管疾病 (CVD) 患者的全因和特定原因死亡率之间的关系。 在这项前瞻性队列研究中，8,024 名既往患有 CVD 的患者（平均年龄来自英国生物银行的年龄：66.6 岁，女性：34.1%）在 2013 年至 2015 年的 7 天内使用腕戴式加速度计测量了他们的 PA。全因死亡率、癌症死亡率和心血管疾病死亡率是通过死亡登记处确定的。 Cox 回归模型和限制三次样条用于评估关联性。人口归因分数 (PAF) 用于估计如果采取更多 PA，可预防的死亡比例。在平均 6.8 年的随访期间，记录了 691 例死亡（273 例死于癌症，219 例死于 CVD）。研究发现，无论 PA 强度如何，PA 持续时间与全因死亡风险之间存在负非线性关联。轻强度 PA (LPA) 的全因死亡率风险比 (HR) 稳定在每周 1800 分钟，中等强度 PA (MPA) 为 320 分钟/周，高强度 PA (VPA) 为 15 分钟/周）。 PA 的最高四分位数与较低的全因死亡风险相关，LPA、MPA、和VPA，分别。在癌症和心血管疾病死亡率方面也观察到类似的关联。此外，VPA 的 PAF 最高，其次是 MPA。我们使用加速度计导出的数据发现所有 PA 强度（LPA、MPA、VPA 和 MVPA）与 CVD 患者的死亡风险之间存在反向非线性关联，但是与之前基于自我报告的 PA 的研究相比，这种关联的程度更大。© 作者 2024。由牛津大学出版社代表欧洲心脏病学会出版。版权所有。如需商业重复使用，请联系 reprints@oup.com 获取转载和转载的翻译权。所有其他权限都可以通过我们网站文章页面上的权限链接通过我们的 RightsLink 服务获得 - 如需了解更多信息，请联系journals.permissions@oup.com。

To investigate the association of accelerometer-measured intensity-specific physical activity (PA) with all-cause and cause-specific mortality among individuals with cardiovascular disease (CVD).In this prospective cohort study, 8,024 individuals with pre-existing CVD (mean age: 66.6 years, female: 34.1%) from the UK Biobank had their PA measured using wrist-worn accelerometers over a 7-day period in 2013-2015. All-cause, cancer, and CVD mortality was ascertained from death registries. Cox regression modelling and restricted cubic splines were used to assess the associations. Population-attributable fractions (PAFs) were used to estimate the proportion of preventable deaths if more PA were undertaken.During an average of 6.8 years of follow-up, 691 deaths (273 from cancer and 219 from CVD) were recorded. An inverse non-linear association was found between PA duration and all-cause mortality risk, irrespective of PA intensity. The hazard ratio (HR) of all-cause mortality plateaued at 1800 minutes/week for light-intensity PA (LPA), 320 minutes/week for moderate-intensity PA (MPA) and 15 minutes/week for vigorous-intensity PA (VPA). The highest quartile of PA associated lower risks for all-cause mortality, with HRs of 0.63 (95% confidence interval [CI]: 0.51-0.79), 0.42 (0.33-0.54) and 0.47 (0.37-0.60) for LPA, MPA, and VPA, respectively. Similar associations were observed for cancer and CVD mortality. Additionally, the highest PAF were noted for VPA, followed by MPA.We found an inverse non-linear association between all intensities of PA (LPA, MPA, VPA, and MVPA) and mortality risk in CVD patients using accelerometer-derived data, but with larger magnitude of the associations than that in previous studies based on self-reported PA.© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.