研究动态
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超越童年:探索小儿毛细胞星形细胞瘤的过渡护理状态。

Beyond childhood: exploring the state of transitional care in pediatric pilocytic astrocytoma.

发表日期:2024 Aug 01
作者: Katherine Chandler, Vivek A Pisharody, Julia Grigorian, Shuting Mao, Tianwen Ma, Arman Jahangiri, Joshua Chern, Kimberly Hoang
来源: Neurosurgical Focus

摘要:

儿童毛细胞星形细胞瘤(PPA)在初次切除后需要长期随访。 PPA 患者的过渡护理情况尚不明确。作者试图检查这些患者的临床病程以及向成人护理的过渡,以更好地描述改善长期护理的机会。 2000 年 5 月至 11 月期间接受 PPA 活检或切除的儿科患者(诊断时年龄小于 18 岁)作者对2022年大型学术中心进行了回顾性回顾。通过图表审查从电子病历中提取患者人口统计数据、肿瘤特征、复发、辅助治疗和随访数据。对截至 2024 年 1 月 1 日年满 18 岁的患者的图表进行了成人随访记录。作者确定了 2000 年 5 月至 2022 年 11 月期间接受 PPA 活检或切除术的 315 名患者。最常见的肿瘤位置是187 例患者(59.4%)实现了后颅窝切除(59.7%)和大体全切除(GTR)。与非 GTR 患者相比,GTR 患者的进展/复发发生频率较低(8.6% vs 41.4%,p < 0.01)。作者发现,在 177 名符合过渡到成人护理年龄的患者中,有 31 名 (17.5%) 成功过渡。从儿科过渡到成人护理的平均年龄为 21.7 岁,最后一次已知成人随访的平均年龄为 25.0 岁。作者发现,与未转为成人护理的患者相比,转为成人护理的患者随访时间更长(12.5 年 vs 7.0 年,p < 0.01),且诊断年龄较大(12.1 年 vs 9.6 岁,p < 0.01)。作者发现, PPA 从儿科护理过渡到成人护理的成功率较低; 17.5% 的符合年龄条件的患者现在由成人提供者照顾,而另外 18.6% 的患者在儿童时期完成了适当的随访,不需要过渡到成人护理。这些发现强调了 PPA 患者从儿科到成人过渡过程的改善机会,特别是对于那些至少 10 年没有随访的非 GTR 患者,在此期间疾病进展的风险被认为是最高的。
Pediatric pilocytic astrocytoma (PPA) requires prolonged follow-up after initial resection. The landscape of transitional care for PPA patients is not well characterized. The authors sought to examine the clinical course and transition to adult care for these patients to better characterize opportunities for improvement in long-term care.Pediatric patients (younger than 18 years at diagnosis) who underwent biopsy or resection for PPA between May 2000 and November 2022 at the authors' large academic center were retrospectively reviewed. Patient demographics, tumor characteristics, recurrence, adjuvant therapies, and follow-up data were extracted from the electronic medical record via chart review. Charts of patients who were 18 years or older as of January 1, 2024, were reviewed for adult follow-up notes.The authors identified 315 patients who underwent biopsy or resection for PPA between May 2000 and November 2022. The most common tumor location was posterior fossa (59.7%), and gross-total resection (GTR) was achieved in 187 patients (59.4%). In patients with GTR, progression/recurrence occurred less frequently (8.6% vs 41.4%, p < 0.01) compared to patients with non-GTR. Among 177 patients found to be age-eligible for transition to adult care, the authors found that 31 (17.5%) successfully transitioned. The average age at transition from pediatric to adult care was 21.7 years, and the average age at last known adult follow-up was 25.0 years. The authors found that patients who transitioned to adult care were followed longer (12.5 vs 7.0 years, p < 0.01) and were diagnosed at an older age (12.1 vs 9.6 years, p < 0.01) than their untransitioned counterparts.The authors found that there was a low rate of successful transition from pediatric to adult care for PPA; 17.5% of age-eligible patients are now cared for by adult providers, whereas an additional 18.6% completed appropriate follow-up during childhood and did not require transition to adult care. These findings underscore opportunities for improvement in the pediatric-to-adult transition process for patients with PPA, particularly for those with non-GTR who were not followed for at least 10 years, during which the risk of disease progression is thought to be highest.