估计新诊断癌症患者的精神障碍患病率与社会经济状况的关系:一项多中心前瞻性观察研究。
Estimating the prevalence of mental disorders in patients with newly diagnosed cancer in relation to socioeconomic status: a multicenter prospective observational study.
发表日期:2024 Jul 31
作者:
U Goerling, J Ernst, P Esser, C Haering, M Hermann, B Hornemann, P Hövel, U Keilholz, D Kissane, O von dem Knesebeck, F Lordick, F Springer, H Zingler, T Zimmermann, C Engel, A Mehnert-Theuerkauf
来源:
ESMO Open
摘要:
本研究的目的是提供新诊断癌症患者与社会经济地位 (SES) 相关的精神障碍 4 周患病率估计。我们招募了诊断后 2 个月内患有确诊实体瘤的新诊断患者。我们根据患者的教育水平、专业资格、收入和职业状况计算了患者的社会经济地位。我们使用《精神障碍诊断与统计手册》第五版临床版(SCID-5-CV)结构化临床访谈来评估精神障碍的 4 周患病率,并使用共病问卷来评估身体损伤程度由于冠状病毒大流行患者的安全限制,我们在查看了他们的病历并亲自或通过邮寄联系他们后,总共确定了 1702 名混合癌症患者。 1030 名患者(53.2% 为男性,平均年龄 60.2 岁)完成了 SCID-5-CV。当根据 SES 分布进行加权以考虑 SES 组的过采样和欠采样时,20.9% [95% 置信区间 (CI) 18.1% 至 23.6%] 的患者被诊断患有任何精神障碍。最常见的是抑郁症(9.9%,95%CI 7.9%至11.9%),创伤和压力相关疾病(6.3%,95%CI 4.7%至7.9%)和焦虑症(4.2%,95%CI 2.9) % 至 5.6%)。我们发现高、中或低 SES 患者的精神障碍没有差异。多变量逻辑回归分析显示,60 岁以下的患者中患有任何精神障碍的患者比例较高[比值比 (OR) 0.42; P < 0.001],在没有伴侣的患者中(OR 1.84;P < 0.001),在女性生殖器官患有肿瘤的女性中(OR 2.45;P < 0.002)以及在具有较高损伤水平的患者中(OR 1.05,95%) CI 1.03-1.07;P < 0.001)。SES 对早期癌症生存者的精神共病没有显着影响。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。
The purpose of this study was to provide the 4-week prevalence estimates of mental disorders in newly diagnosed cancer patients in relation to socioeconomic status (SES).We enrolled newly diagnosed patients with a confirmed solid tumor within 2 months of diagnosis. We calculated patients' SES on the basis of their educational level, professional qualification, income and occupational status. We used the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition-Clinical Version (SCID-5-CV) to assess the 4-week prevalence of mental disorders in addition to a comorbidity questionnaire to assess the level of physical impairment.We identified a total of 1702 patients with mixed cancers after reviewing their medical records and contacting them in person or by post due to coronavirus pandemic patient safety restrictions. 1030 patients (53.2% men, mean age 60.2 years) had completed SCID-5-CV. When weighted according to the SES distribution to account for over- and under-sampling of SES groups, 20.9% [95% confidence interval (CI) 18.1% to 23.6%] of patients were diagnosed with any mental disorder. The most prevalent were depressive disorders (9.9%, 95% CI 7.9% to 11.9%), trauma and stress-related disorders (6.3%, 95% CI 4.7% to 7.9%) and anxiety disorders (4.2%, 95% CI 2.9% to 5.6%). We found no difference in any mental disorder between patients with high, medium or low SES. Multivariate logistic regression analyses revealed higher proportion of patients with any mental disorder in patients younger than 60 years [odds ratio (OR) 0.42; P < 0.001], in patients without a partner (OR 1.84; P < 0.001), in women with tumor in female genital organs (OR 2.45; P < 0.002) and in those with a higher level of impairment (OR 1.05, 95% CI 1.03-1.07; P < 0.001).SES had no significant influence on mental comorbidity in early cancer survivorship.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.