胆管癌（CCA）的预后不佳，需要开发新的治疗方法，例如由磁性纳米颗粒（MNPs）药物诱导的磁热疗法（MHT）来弥补治疗差距。鉴于CCA位于腹腔深处且邻近重要器官，准确预测MNP在肿瘤中的分布所带来的个体化治疗效果和安全性对于MHT在CCA中的进展至关重要。本研究使用 Mimics 软件对临床患者的腹部计算机断层扫描 (CT) 和磁共振成像图像进行三维重建，从而生成代表人体胆道及其邻近区域的逼真数字几何模型结构。随后，利用 COMSOL Multiphysics 软件对 CCA 进行建模，并计算 CCA 中 MNP 的多区域分布所产生的传热定律。不规则CCA中心区域的温度测量约为46°C，肿瘤内大部分区域的温度超过41°C。 CCA内缘温度仅为39～41℃，但可以通过模拟系统调整局部药物浓度来改善。对于具有不同形态和解剖位置的CCA，瘤内MNP的多区域分布模式和药物分布区域的轻微重叠可以协同提高瘤内温度，同时保证治疗安全。本研究强调了将个性化瘤内 MNP 分布策略纳入 MHT 临床实践的实用性和必要性，这可以通过开发结合医学图像数据和数值计算的集成模拟系统来实现。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

The prognosis for Cholangiocarcinoma (CCA) is unfavorable, necessitating the development of new therapeutic approach such as magnetic hyperthermia therapy (MHT) which is induced by magnetic nano-particle (MNPs) drug to bridge the treatment gap. Given the deep location of CCA within the abdominal cavity and proximity to vital organs, accurately predict the individualized treatment effects and safety brought by the distribution of MNPs in tumor will be crucial for the advancement of MHT in CCA. The Mimics software was used in this study to conduct three-dimensional reconstruction of abdominal computed tomography (CT) and magnetic reso-nance imaging images from clinical patients, resulting in the generation of a realistic digital geometric model representing the human biliary tract and its adjacent structures. Subsequently, The COMSOL Multiphysics software was utilized for modeling CCA and calculating the heat transfer law resulting from the multi-regional distribution of MNPs in CCA. The temperature within the central region of irregular CCA measured approximately 46°C, and most areas within the tumor displayed temperatures surpassing 41°C. The temperature of the inner edge of CCA is only 39 ∼ 41℃, however, it can be ameliorated by adjusting the local drug concentration through simulation system. For CCA with diverse morphologies and anatomical locations, the multi-regional distribution patterns of intratumoral MNPs and a slight overlap of drug distribution areas synergistically enhance intratumoral temperature while ensuring treatment safety. The present study highlights the practicality and imperative of incorporating personalized intratumoral MNPs distribution strategy into clinical practice for MHT, which can be achieved through the development of an integrated simulation system which incorporates medical image data and numerical calculations.Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.