非传染性疾病中的天然自噬调节剂：从自噬机制到治疗潜力
Natural autophagy modulators in non-communicable diseases: from autophagy mechanisms to therapeutic potential
影响因子:8.40000
分区:医学2区 / 药学1区 化学：综合2区
发表日期:2025 Jan
作者:
Ting-Ting Xu, Ying-Yi Deng, Xi-Yong Yu, Min Li, Yuan-Yuan Fu
摘要
非传染性疾病（NCD）被定义为一种与不良行为和生活方式密切相关的疾病，例如心血管疾病，癌症和糖尿病。在人口增长和衰老的推动下，NCD已成为世界上最大的疾病负担，迫切需要预防和控制这些慢性疾病。自噬是一种进化保守的过程，可降解溶酶体中细胞衰老或故障细胞器。越来越多的证据表明，自噬在心血管疾病，癌症和其他主要人类疾病的发病机理中起着主要作用，这表明自噬可能是NCD的候选治疗靶标。天然产品/植物化学物质是针对各种疾病的药物的重要资源。最近，天然植物的化合物，例如白藜芦醇，姜黄素和ursolic酸，已被认为是有希望的自噬调节剂。在这篇综述中，我们解决了NCD中天然自噬调节剂开发的最新进展以及当前状态，并提供了最新的体外和体内实验的更新，这些实验为临床研究铺平了道路。具体而言，我们专注于天然自噬调节剂与NCD之间的关系，目的是识别具有治疗潜力的天然自噬调节剂。
Abstract
Non-communicable diseases (NCDs) are defined as a kind of diseases closely related to bad behaviors and lifestyles, e.g., cardiovascular diseases, cancer, and diabetes. Driven by population growth and aging, NCDs have become the biggest disease burden in the world, and it is urgent to prevent and control these chronic diseases. Autophagy is an evolutionarily conserved process that degrade cellular senescent or malfunctioning organelles in lysosomes. Mounting evidence has demonstrated a major role of autophagy in the pathogenesis of cardiovascular diseases, cancer, and other major human diseases, suggesting that autophagy could be a candidate therapeutic target for NCDs. Natural products/phytochemicals are important resources for drugs against a wide variety of diseases. Recently, compounds from natural plants, such as resveratrol, curcumin, and ursolic acid, have been recognized as promising autophagy modulators. In this review, we address recent advances and the current status of the development of natural autophagy modulators in NCDs and provide an update of the latest in vitro and in vivo experiments that pave the way to clinical studies. Specifically, we focus on the relationship between natural autophagy modulators and NCDs, with an intent to identify natural autophagy modulators with therapeutic potential.