非传染性疾病中天然自噬调节剂：从机制到治疗潜力
Natural autophagy modulators in non-communicable diseases: from autophagy mechanisms to therapeutic potential
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影响因子:8.4
分区:医学2区 / 药学1区 化学：综合2区
发表日期:2025 Jan
作者:
Ting-Ting Xu, Ying-Yi Deng, Xi-Yong Yu, Min Li, Yuan-Yuan Fu
DOI:
10.1038/s41401-024-01356-y
摘要
非传染性疾病（NCDs）主要包括心血管疾病、癌症和糖尿病等，主要与不良行为和生活方式密切相关。随着人口增长和老龄化，NCDs已成为全球最大的疾病负担，亟需加强预防和控制。自噬是一种进化上保守的细胞自我清理过程，能降解细胞衰老或功能异常的细胞器。大量证据显示，自噬在心血管疾病、癌症及其他主要疾病的发病机制中发挥关键作用，提示其可能成为治疗NCDs的潜在靶点。天然产物/植物化学物是抗多种疾病药物的重要资源。近年来，来自天然植物的化合物，如白藜芦醇、姜黄素和熊果酸，已被认为是有前景的自噬调节剂。本文综述了天然自噬调节剂在NCDs中的最新研究进展和临床前、临床实验的最新动态，为未来临床研究提供基础。特别关注天然自噬调节剂与NCDs的关系，旨在识别具有治疗潜力的天然自噬调节剂。
Abstract
Non-communicable diseases (NCDs) are defined as a kind of diseases closely related to bad behaviors and lifestyles, e.g., cardiovascular diseases, cancer, and diabetes. Driven by population growth and aging, NCDs have become the biggest disease burden in the world, and it is urgent to prevent and control these chronic diseases. Autophagy is an evolutionarily conserved process that degrade cellular senescent or malfunctioning organelles in lysosomes. Mounting evidence has demonstrated a major role of autophagy in the pathogenesis of cardiovascular diseases, cancer, and other major human diseases, suggesting that autophagy could be a candidate therapeutic target for NCDs. Natural products/phytochemicals are important resources for drugs against a wide variety of diseases. Recently, compounds from natural plants, such as resveratrol, curcumin, and ursolic acid, have been recognized as promising autophagy modulators. In this review, we address recent advances and the current status of the development of natural autophagy modulators in NCDs and provide an update of the latest in vitro and in vivo experiments that pave the way to clinical studies. Specifically, we focus on the relationship between natural autophagy modulators and NCDs, with an intent to identify natural autophagy modulators with therapeutic potential.