癌症治疗当前需要的是一种具有最小或零影响的有针对性的方法。顺便说一句，磁流体热疗（MFH）正在成为一种潜在的治疗策略，预计可以减少实体瘤的副作用。一旦将携带癌细胞的磁性纳米粒子 (MNP) 置于交变磁场下，MFH 会因磁滞、尼尔和布朗弛豫损失而产生热量，从而导致细胞毒性。就 MFH 而言，与其他具有磁性的金属氧化物相比，迄今为止，基于氧化铁的 MNP 得到了最广泛的研究。 MFH 的有效性取决于 MNP 的成分、涂层、尺寸、物理和生物相容性。纯氧化铁和掺杂氧化铁 MNP 已被用来研究它们通过 MFH 杀死癌细胞的效果。本综述评估了纯氧化铁 MNP 和掺杂氧化铁 MNP 的生物相容性及其随后在体外和体内有效杀死癌细胞的热效应。

The need of the hour with respect to cancer treatment is a targeted approach with minimal or nil ramifications. Apropos, magnetic fluid hyperthermia (MFH) is emerging as a potential therapeutic strategy with anticipated reduced side effects for solid tumors. MFH causes cytotoxicity due to the heat generated owing to Hysteresis, Neel, and Brownian relaxation losses once magnetic nanoparticles (MNPs) carrying cancer cells are placed under an alternating magnetic field. With respect to MFH, iron oxide-based MNPs have been most extensively studied to date compared to other metal oxides with magnetic properties. The effectiveness of MFH relies on the composition, coating, size, physical and biocompatible properties of the MNPs. Pure iron oxide and doped iron oxide MNPs have been utilized to study their effects on cancer cell killing through MFH. This review evaluates the biocompatibility of pure and doped iron oxide MNPs and their subsequent hyperthermic effect for effectively killing cancer cells in vitro and in vivo.