偏心肌肉收缩引起不同的生理反应，包括细胞因子谱的调节。尽管与康复相关，但离心肌肉训练对免疫系统的影响从未在多发性硬化症 (MS) 中进行过研究。检查白细胞介素 4 (IL-4)、IL-6、IL-10、IL 的即时细胞因子反应对多发性硬化症患者进行适度离心训练后，观察 -17a、干扰素-γ 和肿瘤坏死因子-α。此外，进一步研究静息时的全身细胞因子水平与活动能力和下肢功能强度的临床测量之间的关联。观察性研究。第一部分包括基线细胞因子测量的血液采样。随后，参与者完成了一系列与活动能力和下肢力量相关的临床评估，即计时起立测试、五次重复坐站测试（5STS）、四方格测试步进测试和两分钟步行测试。第二节课包括离心运动训练，然后进行第二次血液采样，以评估对离心训练的急性细胞因子反应。该课程包括 10 项练习，重点关注躯干和下肢的力量。 27 名多发性硬化症 (pwMS) 患者参与了这项研究，平均年龄为 40.1 岁。基线与离心训练结束后的细胞因子浓度值没有差异。 5STS 解释了与干扰素 γ 相关的 30.3%、与 IL-4 相关的 14.8%、与 IL-10 相关的 13.8%。 离心训练不会影响血液中的细胞因子浓度，因此不会提高亲和力。 -炎症反应，因此，可以在康复环境中对 pwMS 进行。© 作者，2024。

Eccentric muscle contractions elicit distinct physiological responses, including modulation of the cytokine profile. Although relevant for rehabilitation, the effect of eccentric muscle training on the immune system has never been investigated in multiple sclerosis (MS).Examine the immediate cytokine response of interleukin-4 (IL-4), IL-6, IL-10, IL-17a, interferon-gamma, and tumor necrosis factor-alpha after a moderate eccentric training session in individuals with MS. Additionally, further investigate the association between systemic cytokine levels at rest and clinical measures of mobility and lower limb functional strength.Observational study.The first session included blood sampling for baseline cytokine measures. Subsequently, the participant completed a battery of clinical assessments related to mobility and lower limb strength, that is, the Timed-Up-and-Go Test, Five-Repetition-Sit-to-Stand-Test (5STS), Four-Square-Step-Test, and Two-Minute-Walk-Test. The second session included the eccentric exercise training session, followed by a second blood sampling to assess the acute cytokine response to the eccentric training bout. This session comprised 10 exercises concentrating on the strength of the trunk and lower extremities.Twenty-seven people with MS (pwMS), with a mean age of 40.1 years, participated in the study. No difference was demonstrated in the cytokine concentration values between baseline and immediately after the eccentric training session. The 5STS explained 30.3% of the variance associated with interferon-gamma, 14.8% with IL-4, and 13.8% with IL-10.An eccentric training bout does not impact cytokine concentration in the blood and, consequently, does not boost a pro-inflammatory response, thus, it can be performed on pwMS in a rehabilitation setting.© The Author(s), 2024.