目的探讨OSCC中PD-L1的表达与患者临床病理特征及预后的关系。我们回顾性分析了381例OSCC患者的临床病理资料及预后。对OSCC肿瘤标本进行免疫组化染色，根据联合阳性评分（CPS）评估PD-L1的表达水平。采用Kaplan-Meier分析确定PD-L1表达和临床病理特征对患者预后的影响。通过单因素和多因素Cox回归分析确定影响患者预后的危险因素。PD-L1过表达与颈部淋巴结转移（p = 0.018）、较差的临床分期（p = 0.022）、较差的肿瘤分化程度显着相关（ p = 0.046），并且侵入深度（DOI）更差（p = 0.003）。较差的临床分期和肿瘤分化程度与患者较差的 OS 和 DSS 显着相关。 PD-L1表达与OSCC患者的预后无关。PD-L1高表达与OSCC患者较高的肿瘤恶性程度显着相关。较差的临床分期和肿瘤分化程度与 OSCC 患者的不良预后相关。我们的结果可以帮助临床医生为患者制定更合适的个体化治疗策略，从而改善他们的治疗结果。© 2024 John Wiley

To investigate the relationship between the expression of PD-L1 in OSCC and the clinicopathological features and prognosis of patients.We retrospectively analyzed the clinicopathological data and prognosis of 381 OSCC patients. Immunohistochemical staining was performed on OSCC tumor specimens, and the expression level of PD-L1 was evaluated according to the combined positive score (CPS). Kaplan-Meier analysis was used to identify the effect of PD-L1 expression and clinicopathological features on the prognosis of patients. Univariate and multivariate Cox regression analyses were conducted to determine the hazard factors affecting the prognosis of patients.PD-L1 overexpression was significantly associated with cervical lymph node metastasis (p = 0.018), worse clinical stage (p = 0.022), worse tumor differentiation (p = 0.046), and worse depth of invasion (DOI) (p = 0.003). Poorer clinical stage and degree of tumor differentiation were significantly associated with poorer OS and DSS in patients. PD-L1 expression was not associated with prognosis in patients with OSCC.High PD-L1 expression was significantly associated with higher tumor malignancy in OSCC patients. Poorer clinical stage and degree of tumor differentiation were associated with poor prognosis in OSCC patients. Our results may help clinicians develop more appropriate individualized treatment strategies for their patients, thus improving their outcomes.© 2024 John Wiley & Sons Ltd.