与卡波西肉瘤相关的疱疹病毒共同感染的艾滋病毒感染者具有独特的 HIV Tat 特征和较高的抗逆转录病毒病毒学失败率，这在卡波西肉瘤患者中更为明显。
People living with HIV co-infected with the Kaposi Sarcoma-associated Herpes Virus have a distinct HIV Tat profile and higher rates of antiretroviral virologic failure, more evident among those with Kaposi's sarcoma.
发表日期：2024 Aug
作者：
Dalila G Suterio, James R Hunter, Simone B Tenore, Sidnei R Pimentel, Juliana Galinskas, Danilo A Dias, Débora C Bellini, Paulo A Ferreira, Ricardo Sobhie Diaz
来源：
JOURNAL OF MEDICAL VIROLOGY
摘要：
卡波西肉瘤（KS）是一种血管起源的肿瘤，由卡波西肉瘤相关疱疹病毒（KSHV）触发，促进血管生成和内皮细胞生长。当与 HIV 相关时，KSHV 变得更具攻击性并迅速进化。 HIV-1 TAT 蛋白通过促进血管生成和增加 KSHV 复制，对于发展 AIDS 相关的 KS 至关重要。因此，我们评估了具有（病例组，n = 36）或不具有KS的HIV感染者（PLHIV）人群中tat基因第一个外显子的遗传图谱，随后有（阳性对照组，n = 46）和无KSHV感染（阴性对照组，n = 24）；所有接受抗逆转录病毒治疗的个体。病例组遗传多样性、DN/DS比值、tat第1外显子遗传熵较高,其次为阳性对照组,高于阴性对照组。阳性选择的tat密码子个数病例组为7个，阳性对照组为6个，阴性对照组为1个。病例组和阳性对照组的HIV病毒载量低于检测限的患病率相当，但低于阴性对照组。阴性对照组的平均CD4 T细胞计数较高，其次是阳性对照组，最后是病例组。这些结果强调了 KSHV 在抗逆转录病毒治疗中的负面影响，以及开发 KS 的 PLHIV 中的 HIV 特异性 TAT 特征。© 2024 Wiley periodicals LLC。
Kaposi sarcoma (KS) is a neoplasm of vascular origin that promotes angiogenesis and the growth of endothelial cells triggered by the Kaposi Sarcoma-associated Herpes Virus (KSHV). When associated with HIV, KSHV becomes more aggressive and rapidly evolves. The HIV-1 TAT protein can be essential in developing AIDS-associated KS by promoting angiogenesis and increasing KSHV replication. Therefore, we evaluated the genetic profile of the first exon of tat gene among groups of people living with HIV (PLHIV) with (case group, n = 36) or without KS, this later with (positive control group, n = 46) and without KSHV infection (negative control group, n = 24); all individuals under antiretroviral therapy. The genetic diversity, the DN/DS ratio, and the genetic entropy of the first exon of tat were higher in the case group, followed by the positive control group, which was higher than the negative control group. The number of tat codons under positive selection was seven in the case group, six in the positive control group, and one in the negative control group. The prevalence of HIV viral loads below the detection limit was equal in the case and positive control groups, which were lower than in the negative control group. The mean CD4+ T cell counts were higher in the negative control group, followed by the positive control group, and followed by the case group. These results emphasize the negative influence of KSHV in antiretroviral treatment, as well as the HIV-specific TAT profile among PLHIV who developed KS.© 2024 Wiley Periodicals LLC.