居住在西方国家的黑人男性更容易患前列腺癌 (PCa)，死亡率更高，而且初次诊断时比一般人群更年轻。除了遗传和环境因素外，造成这些种族差异的原因还可以归因于健康的社会决定因素，例如该人群健康素养低、卫生服务意识差等。关于黑人男性 PCa 的实验室测试知之甚少。在这项初步研究中。我们调查了种族是否影响健康男性的 PSA 分子形式、PHI、雌二醇和睾酮水平。我们发现健康黑人男性的 PHI、[-2]proPSA/fPSA 和睾酮/雌二醇比率较低。即使是一项小型研究，我们的研究结果也是如此人群可能会产生相关的临床影响。因为 PCa 筛查对于患有具有临床意义的 PCa 风险高的黑人男性尤其重要。需要基于 PSA 的筛查，并且必须避免过度诊断。我们的发现可能特别有影响力。未来对更多人群的研究需要考虑种族特定的实验室测试阈值是否有助于减少前列腺癌诊断中的种族不平等。

Black men residing in Western countries are more likely to develop prostate cancer (PCa), have higher mortality and are younger than the general population at initial diagnosis. In addition to genetic and environmental factors, the reasons for these racial disparities can also be attributed to social determinants of health such as low health literacy of this population and poor awareness of health services. Little is known about laboratory tests for PCa in black men.In this preliminary study. we investigated whether ethnicity affect PSA molecular forms, PHI, estradiol and testosterone levels in healthy men.We found that healthy black men had lower PHI, [-2]proPSA/fPSA and testosterone/estradiol ratios.Our findings even if on a small study population could have a relevant clinical impact. since PCa screening is particularly relevant in black men who are at high risk of clinically significant PCa. PSA-based screening is needed and overdiagnosis must be avoided. Our findings could be particularly impactful. Future research on larger population needs to consider whether ethnicity specific laboratory tests thresholds could help to reduce the ethnic inequalities in prostate cancer diagnosis.