假包膜切除术是一种公认​​的有效方法，可实现功能性垂体神经内分泌肿瘤（PitNET）的内分泌缓解。然而，其在非功能性 PitNET（NF-PitNETs）方面的优势尚未确立。本研究旨在阐明假包膜切除术对长期随访中预防 NF-PitNET 复发的贡献。这项回顾性研究包括 132 例接受肿瘤全切除术并术后随访 5 年以上的患者。将患者分为接受全假包膜切除术的患者 (n = 67) 和未接受全假包膜切除术的患者 (n = 65)。非假包膜（非假包膜）切除组包括接受部分假包膜切除的患者以及术中假包膜未切除、不存在或无法识别的患者。主要观察指标为肿瘤复发率和复发部位。非假性帽切除组中，海绵窦肿瘤复发2例（3.1%），垂体窝肿瘤复发5例（7.7%）。假包膜（pseudocap）切除组中，仅有2例（3.0%）患者出现海绵窦肿瘤复发，0例患者出现垂体窝肿瘤复发。与假性帽切除组相比，非假性帽切除组更容易发生垂体窝肿瘤复发（p = 0.0267）。多变量回归分析显示，假包膜切除术是降低垂体窝肿瘤复发率的重要因素（p = 0.0107）。假包膜切除术可以降低肿瘤复发率，并改善长期随访中 NF-PitNET 的管理。向上。

Pseudocapsular resection is a well-recognized, useful approach to achieve endocrinological remission in functioning pituitary neuroendocrine tumors (PitNETs). However, its advantage in nonfunctioning PitNETs (NF-PitNETs) has not been established. This study aimed to clarify the contribution of pseudocapsular resection to the prevention of NF-PitNET recurrence in long-term follow-up.This retrospective study included 132 patients who underwent total tumor removal and were followed for more than 5 years after surgery. The patients were categorized into those who underwent total pseudocapsular resection (n = 67) and those who did not (n = 65). The nonpseudocapsule (nonpseudocap) resection group included patients who underwent partial pseudocapsular resection and those in whom the pseudocapsule was not resected, did not exist, or could not be identified during surgery. The main outcome measures were the tumor recurrence rate and site of recurrence.In the nonpseudocap resection group, 2 patients (3.1%) had tumor recurrence in the cavernous sinus and 5 (7.7%) had tumor recurrence in the pituitary fossa. In the pseudocapsule (pseudocap) resection group, only 2 patients (3.0%) had tumor recurrence in the cavernous sinus and 0 patients had tumor recurrence in the pituitary fossa. Tumor recurrence in the pituitary fossa was more likely to occur in the nonpseudocap resection group than in the pseudocap resection group (p = 0.0267). Multivariate regression analysis revealed that pseudocapsular resection was a significant factor for reducing the tumor recurrence rate in the pituitary fossa (p = 0.0107).Pseudocapsular resection may reduce the rate of tumor recurrence and improve the management of NF-PitNETs in long-term follow-up.