利用分子扩散评估中的光线：鉴别各种病理状态
Light in evaluation of molecular diffusion in tissues: Discrimination of pathologies
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影响因子:17.6
分区:医学1区 Top / 药学1区
发表日期:2024 Sep
作者:
Luís R Oliveira, Maria R Pinheiro, Daria K Tuchina, Polina A Timoshina, Maria I Carvalho, Luís M Oliveira
DOI:
10.1016/j.addr.2024.115420
摘要
评估组织中不同分子扩散特性的研究在皮肤科/美容学、临床医学、植入学和食品保鲜等多个领域具有重要意义。本文综述了近期利用动力光谱测量技术评估不同组织中分子扩散特性的研究。通过将离体组织浸泡于药剂中或在体内局部应用药剂，可以通过动力准直透射或散射反射光谱来评估其扩散特性。利用此方法，近期研究成功区分了健康与疾病组织中药剂的扩散差异，特别是在癌症和糖尿病的病例中。在癌症方面，还观察到从健康到癌变的结直肠和肾脏组织中移动水分含量的增加（5%）。考虑到在低温保存（冷冻保存）中应用某些药剂以防止组织变质，且这些药剂的加入过程可能被逆转，本文也对这些领域的相关研究进行了讨论。未来，基于宽带光学光谱技术的药剂扩散特性评估及其在生理诊断中的应用，为优化水果的甜度或评估毒素在组织中的扩散、以及对解毒剂的治疗优化提供了潜在方向。
Abstract
The evaluation of the diffusion properties of different molecules in tissues is a subject of great interest in various fields, such as dermatology/cosmetology, clinical medicine, implantology and food preservation. In this review, a discussion of recent studies that used kinetic spectroscopy measurements to evaluate such diffusion properties in various tissues is made. By immersing ex vivo tissues in agents or by topical application of those agents in vivo, their diffusion properties can be evaluated by kinetic collimated transmittance or diffuse reflectance spectroscopy. Using this method, recent studies were able to discriminate the diffusion properties of agents between healthy and diseased tissues, especially in the cases of cancer and diabetes mellitus. In the case of cancer, it was also possible to evaluate an increase of 5% in the mobile water content from the healthy to the cancerous colorectal and kidney tissues. Considering the application of some agents to living organisms or food products to protect them from deterioration during low temperature preservation (cryopreservation), and knowing that such agent inclusion may be reversed, some studies in these fields are also discussed. Considering the broadband application of the optical spectroscopy evaluation of the diffusion properties of agents in tissues and the physiological diagnostic data that such method can acquire, further studies concerning the optimization of fruit sweetness or evaluation of poison diffusion in tissues or antidote application for treatment optimization purposes are indicated as future perspectives.