在最近成功的概念验证临床试验的推动下，癌症免疫疗法引发了一波癌症研究浪潮。然而，在其快速发展过程中也出现了一些障碍，包括广泛的不良反应、缺乏可靠的生物标志物、肿瘤复发和耐药性。纳米医学的整合可能会改善当前的癌症免疫疗法。纳米粒子超大的比表面积、极小的尺寸以及易于修饰的表面使其能够在体内选择性地检测细胞并杀死癌细胞。在癌症免疫疗法和癌症纳米医学的交叉领域，这两种方法在治疗各种癌症方面出现了令人兴奋的协同应用，表明这两种治疗方式的组合有可能带来癌症治疗的新范例。本综述讨论了当前免疫疗法的现状，并探讨了纳米医学平台通过协同两种方法使癌症免疫疗法变得更加强大和精确的可能机会。© 2024。作者。

Cancer immunotherapy has sparked a wave of cancer research, driven by recent successful proof-of-concept clinical trials. However, barriers are emerging during its rapid development, including broad adverse effects, a lack of reliable biomarkers, tumor relapses, and drug resistance. Integration of nanomedicine may ameliorate current cancer immunotherapy. Ultra-large surface-to-volume ratio, extremely small size, and easy modification surface of nanoparticles enable them to selectively detect cells and kill cancer cells in vivo. Exciting synergistic applications of the two approaches have emerged in treating various cancers at the intersection of cancer immunotherapy and cancer nanomedicine, indicating the potential that the combination of these two therapeutic modalities can lead to new paradigms in the treatment of cancer. This review discusses the status of current immunotherapy and explores the possible opportunities that the nanomedicine platform can make cancer immunotherapy more powerful and precise by synergizing the two approaches.© 2024. The Author(s).