肠道屏障在人体生理学中发挥着至关重要的作用，无论是在稳态还是病理条件下。肠道屏障的破坏是胃肠道炎症性疾病（例如炎症性肠病）发病机制的重要因素。肠道微生物群对肠道疾病的深远影响引起了人们对通过饮食干预、益生菌和粪便微生物群移植作为增强肠道屏障完整性的潜在方法来控制肠道微生物群的极大兴趣。许多研究强调了特定微生物群及其相关代谢物的保护作用。近年来，越来越多的研究表明，Akkermansia muciniphila (A. muciniphila, Am) 在多种疾病中发挥着有益作用，包括糖尿病、肥胖、衰老、癌症和代谢综合征。它作为影响肠道菌群和肠道屏障的调节剂而越来越受欢迎，并被认为是“新一代益生菌”。因此，它可能代表肠道疾病的潜在靶点和有前途的治疗选择。本文系统总结了Am在肠道中的作用。具体来说，我们仔细讨论了以Am为代表的有益细菌未来需要解决的关键科学问题，这可能为针对Am的药物在临床治疗中的应用提供见解。© 2024。作者。

Intestinal barriers play a crucial role in human physiology, both in homeostatic and pathological conditions. Disruption of the intestinal barrier is a significant factor in the pathogenesis of gastrointestinal inflammatory diseases, such as inflammatory bowel disease. The profound influence of the gut microbiota on intestinal diseases has sparked considerable interest in manipulating it through dietary interventions, probiotics, and fecal microbiota transplantation as potential approaches to enhance the integrity of the intestinal barrier. Numerous studies have underscored the protective effects of specific microbiota and their associated metabolites. In recent years, an increasing body of research has demonstrated that Akkermansia muciniphila (A. muciniphila, Am) plays a beneficial role in various diseases, including diabetes, obesity, aging, cancer, and metabolic syndrome. It is gaining popularity as a regulator that influences the intestinal flora and intestinal barrier and is recognized as a 'new generation of probiotics'. Consequently, it may represent a potential target and promising therapy option for intestinal diseases. This article systematically summarizes the role of Am in the gut. Specifically, we carefully discuss key scientific issues that need resolution in the future regarding beneficial bacteria represented by Am, which may provide insights for the application of drugs targeting Am in clinical treatment.© 2024. The Author(s).